DegronMD

Uniprot ID: Q01196

Source protein: Runt-related transcription factor 1

Source gene: RUNX1

Class: DEG_SCF_FBW7_1

Location: 330:335

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 62.5667

COIL: 0.9135

CONS_SCORE: 0.4033

DSS_SCORE: 0.3032

HELIX: 0.0257

FCONS_SCORE: 1.065

RIG_SCORE: 0.7196

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T323M	TCGA-DI-A1BU	UCEC	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.1389
p.T323M	DO42023	UCEC	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.1389
p.R334H	TCGA-S9-A6TS	LGG	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.8244
p.R334H	DO50181	LGG	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.8244
p.D344N	DO233791	GACA	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.0833
p.R334S	DO229036	LICA	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.7427
p.Q335H	SIDM00377	Other Sarcomas	GDSC	PTPVTS	DEG_SCF_FBW7_1	0.7582
p.S342L	ACH-000223	Breast Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.1389
p.Q335L	ACH-000851	Lung Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.7765
p.M341V	ACH-000919	Gastric Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01196	Runt-related transcription factor 1	DEG_SCF_FBW7_1	330:335	PTPVTS	FBXW7	0.9977	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SCF_FBW7_1	908:913	PTPVTS	FBXW7	0.9937	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SCF_FBW7_1	3508:3513	PTPVTS	FBXW7	0.7023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons