DegronMD

Uniprot ID: Q15652

Source protein: Probable JmjC domain-containing histone demethylation protein 2C

Source gene: JMJD1C

Class: DEG_SCF_FBW7_1

Location: 908:913

E3 ligase: FBXW7

DEGRON score: 0.9937

ASA_SCORE: 79.9833

COIL: 0.9397

CONS_SCORE: 0.3873

DSS_SCORE: 0.5184

HELIX: 0.0283

FCONS_SCORE: 1.0566

RIG_SCORE: 0.6717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D915E	TCGA-2Z-A9J5	KIRP	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.2778
p.S921C	TCGA-44-6778	LUAD	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.1111
p.S900Y	TCGA-AP-A1DV	UCEC	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.1111
p.S900Y	TCGA-AX-A06F	UCEC	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.1111
p.W904C	TCGA-DK-AA6R	BLCA	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.2222
p.W904R	TCGA-G7-6790	KIRP	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.2222
p.L920F	TCGA-H7-A6C4	HNSC	TCGA	PTPVTS	DEG_SCF_FBW7_1	0.1389
p.A908E	DO229006	LICA	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.7701
p.Q915K	DO25320	LUAD	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.2778
p.A909V	DO36542	READ	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.6936
p.S923Y	DO41109	UCEC	ICGC	PTPVTS	DEG_SCF_FBW7_1	0.0556
p.P901S	SIDM00545	Melanoma	GDSC	PTPVTS	DEG_SCF_FBW7_1	0.1389
p.P901S	ACH-000987	Skin Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.1389
p.P901S	Mewo	skin	COSMIC	PTPVTS	DEG_SCF_FBW7_1	0.1389
p.S902C	ACH-000982	Colon/Colorectal Cancer	CCLE	PTPVTS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01196	Runt-related transcription factor 1	DEG_SCF_FBW7_1	330:335	PTPVTS	FBXW7	0.9977	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SCF_FBW7_1	908:913	PTPVTS	FBXW7	0.9937	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SCF_FBW7_1	3508:3513	PTPVTS	FBXW7	0.7023	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons