DegronMD

Uniprot ID: Q7Z6Z7

Source protein: E3 ubiquitin-protein ligase HUWE1

Source gene: HUWE1

Class: DEG_SCF_FBW7_1

Location: 3240:3246

E3 ligase: FBXW7

DEGRON score: 0.8677

ASA_SCORE: 80.7

COIL: 0.7586

CONS_SCORE: 0.3191

DSS_SCORE: 0.4738

HELIX: 0.1289

FCONS_SCORE: 0.8754

RIG_SCORE: 0.7419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q3231K	TCGA-29-1777	OV	TCGA	IETPKLT	DEG_SCF_FBW7_1	0.0833
p.Q3231K	DO28071	OV	ICGC	IETPKLT	DEG_SCF_FBW7_1	0.0833
p.R3232C	TCGA-AJ-A8CW	UCEC	TCGA	IETPKLT	DEG_SCF_FBW7_1	0.1111
p.R3232C	TCGA-BR-8296	STAD	TCGA	IETPKLT	DEG_SCF_FBW7_1	0.1111
p.R3232C	DO38539	STAD	ICGC	IETPKLT	DEG_SCF_FBW7_1	0.1111
p.R3232C	DO52400	UCEC	ICGC	IETPKLT	DEG_SCF_FBW7_1	0.1111
p.R3232C	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IETPKLT	DEG_SCF_FBW7_1	0.1111
p.R3232C	ACH-002256	Leukemia	CCLE	IETPKLT	DEG_SCF_FBW7_1	0.1111
p.R3232C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IETPKLT	DEG_SCF_FBW7_1	0.1111
p.E3237D	TCGA-DF-A2KU	UCEC	TCGA	IETPKLT	DEG_SCF_FBW7_1	0.25
p.E3237D	DO223286	UCEC	ICGC	IETPKLT	DEG_SCF_FBW7_1	0.25
p.S3233R	TCGA-DX-A6YV	SARC	TCGA	IETPKLT	DEG_SCF_FBW7_1	0.1389
p.S3233R	DO220011	SARC	ICGC	IETPKLT	DEG_SCF_FBW7_1	0.1389
p.S3248N	TCGA-VS-A9UY	CESC	TCGA	IETPKLT	DEG_SCF_FBW7_1	0.2778
p.S3248N	DO219742	CESC	ICGC	IETPKLT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SCF_FBW7_1	3240:3246	IETPKLT	FBXW7	0.8677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons