DegronMD

Uniprot ID: Q7Z6Z7

Source protein: E3 ubiquitin-protein ligase HUWE1

Source gene: HUWE1

Class: SCF_FBXL2

Location: 2598:2605

E3 ligase: FBXL2

DEGRON score: 0.6258

ASA_SCORE: 80.2375

COIL: 0.6573

CONS_SCORE: 0.3201

DSS_SCORE: 0.2184

HELIX: 0.1169

FCONS_SCORE: 0.8965

RIG_SCORE: 0.7253

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2593N	TCGA-B5-A11E	UCEC	TCGA	LQSRGRAR	SCF_FBXL2	0.6389
p.S2593N	DO41644	UCEC	ICGC	LQSRGRAR	SCF_FBXL2	0.6389
p.R2603Q	TCGA-BR-4368	STAD	TCGA	LQSRGRAR	SCF_FBXL2	0.6218
p.R2603Q	DO38715	STAD	ICGC	LQSRGRAR	SCF_FBXL2	0.6218
p.R2605H	TCGA-BR-7707	STAD	TCGA	LQSRGRAR	SCF_FBXL2	0.7133
p.R2605H	DO38487	STAD	ICGC	LQSRGRAR	SCF_FBXL2	0.7133
p.R2601W	TCGA-D1-A167	UCEC	TCGA	LQSRGRAR	SCF_FBXL2	0.8634
p.R2601W	DO40978	UCEC	ICGC	LQSRGRAR	SCF_FBXL2	0.8634
p.L2590I	TCGA-KO-8404	KICH	TCGA	LQSRGRAR	SCF_FBXL2	0.1111
p.L2590I	DO220545	KICH	ICGC	LQSRGRAR	SCF_FBXL2	0.1111
p.V2613I	DO227549	COCA	ICGC	LQSRGRAR	SCF_FBXL2	0.1111
p.R2603W	DO228732	GACA	ICGC	LQSRGRAR	SCF_FBXL2	0.7523
p.R2605C	DO229234	THCA	ICGC	LQSRGRAR	SCF_FBXL2	0.719
p.R2605C	SIDM01088	Endometrial Carcinoma	GDSC	LQSRGRAR	SCF_FBXL2	0.719
p.R2605C	ACH-000965	Endometrial/Uterine Cancer	CCLE	LQSRGRAR	SCF_FBXL2	0.719
p.R2605C	ACH-001786	Colon/Colorectal Cancer	CCLE	LQSRGRAR	SCF_FBXL2	0.719
p.R2605C	RL95-2	endometrium	COSMIC	LQSRGRAR	SCF_FBXL2	0.719
p.R2609C	SNU-1040	large_intestine	COSMIC	LQSRGRAR	SCF_FBXL2	0.2222
p.R2596C	RL95-2	endometrium	COSMIC	LQSRGRAR	SCF_FBXL2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	SCF_FBXL2	2598:2605	LQSRGRAR	FBXL2	0.6258	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons