DegronMD

Uniprot ID: Q7Z6Z7

Source protein: E3 ubiquitin-protein ligase HUWE1

Source gene: HUWE1

Class: DEG_SPOP_SBC_1

Location: 3486:3490

E3 ligase: SPOP

DEGRON score: 0.9297

ASA_SCORE: 85.44

COIL: 0.9226

CONS_SCORE: 0.2952

DSS_SCORE: 0.5762

HELIX: 0.0272

FCONS_SCORE: 0.9118

RIG_SCORE: 0.6218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3477V	TCGA-19-1386	GBM	TCGA	ATSTT	DEG_SPOP_SBC_1	0.0833
p.G3477V	DO10902	GBM	ICGC	ATSTT	DEG_SPOP_SBC_1	0.0833
p.S3476A	TCGA-EO-A3AY	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.0556
p.S3476A	DO43202	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.0556
p.S3491Y	TCGA-EY-A215	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.3056
p.S3491Y	TCGA-ND-A4WC	UCS	TCGA	ATSTT	DEG_SPOP_SBC_1	0.3056
p.S3491Y	DO42665	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.S3488T	DO48727	LIRI	ICGC	ATSTT	DEG_SPOP_SBC_1	0.6005
p.A3486T	ACH-000990	Endometrial/Uterine Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons