DegronMD

Uniprot ID: Q9UHR5

Source protein: SAP30-binding protein

Source gene: SAP30BP

Class: DEG_SPOP_SBC_1

Location: 235:239

E3 ligase: SPOP

DEGRON score: 0.6492

ASA_SCORE: 89

COIL: 0.9344

CONS_SCORE: 0.2746

DSS_SCORE: 0.4788

HELIX: 0.0426

FCONS_SCORE: 0.9259

RIG_SCORE: 0.7324

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G226C	TCGA-05-4384	LUAD	TCGA	ATSTT	DEG_SPOP_SBC_1	0.0833
p.A243T	TCGA-AB-2807	LAML	TCGA	ATSTT	DEG_SPOP_SBC_1	0.2222
p.A248V	TCGA-AP-A1DK	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.0833
p.G230A	TCGA-AT-A5NU	KIRP	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1944
p.A227T	DO21589	LAML	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1111
p.R237K	DO220873	MELA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7237
p.T238I	DO229470	SKCA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7078
p.A232V	DO42033	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.25
p.S243L	DO41331	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons