DegronMD - Q5T2D2(TREML2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G189V	TCGA-12-0775	GBM	TCGA	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1944
p.G189V	DO14133	GBM	ICGC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1944
p.S196R	TCGA-49-AAR0	LUAD	TCGA	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.7427
p.S196R	DO218917	LUAD	ICGC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.7427
p.S239L	TCGA-A6-6653	COAD	TCGA	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation blocking phosphorylation signal	0.5278
p.S239L	DO10373	COAD	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation blocking phosphorylation signal	0.5278
p.T241I	TCGA-AP-A054	UCEC	TCGA	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1389
p.T241I	DO42256	UCEC	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1389
p.P202H	TCGA-BA-A6DA	HNSC	TCGA	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.P202H	DO44448	HNSC	ICGC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.2222
p.S199R	TCGA-BA-A6DA	HNSC	TCGA	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.S199R	DO44448	HNSC	ICGC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.S248N	TCGA-EO-A3B0	UCEC	TCGA	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5958
p.S248N	DO219773	UCEC	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5958
p.R204K	TCGA-GN-A262	SKCM	TCGA	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1667
p.R204K	DO231782	LINC	ICGC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1667
p.R204K	DO37515	SKCM	ICGC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1667
p.A194D	DO228976	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.7793
p.T198N	DO229028	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation altering degron motif	0.7055
p.S248G	DO230950	LUSC	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5882
p.S248G	DO224638	LUSC	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.5882
p.S248R	SIDM00001	Other Blood Cancers	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM00521	Small Cell Lung Carcinoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM00984	Other Blood Cancers	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM00623	Other Blood Cancers	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM01186	Breast Carcinoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM00098	Mesothelioma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM01681	Non-Cancerous	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM00205	Ewing's Sarcoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM00980	Gastric Carcinoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.S248R	SIDM00628	Breast Carcinoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation altering degron motif	0.6316
p.T193A	SIDM01169	Ovarian Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.T193A	SIDM01716	Non-Cancerous	GDSC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.T193A	SIDM00175	Melanoma	GDSC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.T193A	SIDM01772	Mesothelioma	GDSC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.T193A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.3056
p.G243R	SIDM00309	Mesothelioma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1944
p.G243R	ACH-002131	Lung Cancer	CCLE	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1944
p.G243R	H2803	pleura	COSMIC	SRSLLNRLP	DEG_APCC_DBOX_1	248:256	Mutation rewiring degron network	0.1944
p.M206T	SIDM01608	Endometrial Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1111
p.M206T	ACH-000990	Endometrial/Uterine Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1111
p.S186C	ACH-001611	Brain Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	194:198	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TREML2

UniProt ID: Q5T2D2

Entrez ID: 79865

Protein name: Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TREML2 in