DegronMD

Uniprot ID: Q5T2D2

Source protein: Trem-like transcript 2 protein

Source gene: TREML2

Class: DEG_APCC_DBOX_1

Location: 248:256

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.78

ASA_SCORE: 84.0444

COIL: 0.8039

CONS_SCORE: 0.3384

DSS_SCORE: 0.3217

HELIX: 0.1412

FCONS_SCORE: 0.7662

RIG_SCORE: 0.7818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S239L	TCGA-A6-6653	COAD	TCGA	SRSLLNRLP	DEG_APCC_DBOX_1	0.5278
p.S239L	DO10373	COAD	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	0.5278
p.T241I	TCGA-AP-A054	UCEC	TCGA	SRSLLNRLP	DEG_APCC_DBOX_1	0.1389
p.T241I	DO42256	UCEC	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	0.1389
p.S248N	TCGA-EO-A3B0	UCEC	TCGA	SRSLLNRLP	DEG_APCC_DBOX_1	0.5958
p.S248N	DO219773	UCEC	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	0.5958
p.S248G	DO230950	LUSC	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	0.5882
p.S248G	DO224638	LUSC	ICGC	SRSLLNRLP	DEG_APCC_DBOX_1	0.5882
p.S248R	SIDM00001	Other Blood Cancers	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM00521	Small Cell Lung Carcinoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM00984	Other Blood Cancers	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM00623	Other Blood Cancers	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM01186	Breast Carcinoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM00098	Mesothelioma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM01681	Non-Cancerous	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM00205	Ewing's Sarcoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM00980	Gastric Carcinoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.S248R	SIDM00628	Breast Carcinoma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.6316
p.G243R	SIDM00309	Mesothelioma	GDSC	SRSLLNRLP	DEG_APCC_DBOX_1	0.1944
p.G243R	ACH-002131	Lung Cancer	CCLE	SRSLLNRLP	DEG_APCC_DBOX_1	0.1944
p.G243R	H2803	pleura	COSMIC	SRSLLNRLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T2D2	Trem-like transcript 2 protein	DEG_APCC_DBOX_1	248:256	SRSLLNRLP	APC,CDC20,FZR1	0.78	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons