DegronMD - Q9H7T9(AUNIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S140F	TCGA-A8-A09N	BRCA	TCGA	MKTPFST	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944
p.S140F	DO5081	BRCA	ICGC	MKTPFST	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944
p.Y250H	TCGA-AO-A128	BRCA	TCGA	AKENR	DEG_APCC_KENBOX_2	237:241	Mutation rewiring degron network	0.0833
p.Y250H	DO5326	BRCA	ICGC	AKENR	DEG_APCC_KENBOX_2	237:241	Mutation rewiring degron network	0.0833
p.G227C	TCGA-AX-A2HD	UCEC	TCGA	AKENR	DEG_APCC_KENBOX_2	237:241	Mutation rewiring degron network	0.0556
p.G227C	DO42608	UCEC	ICGC	AKENR	DEG_APCC_KENBOX_2	237:241	Mutation rewiring degron network	0.0556
p.A130V	TCGA-BH-A0HF	BRCA	TCGA	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1667
p.A130V	DO1749	BRCA	ICGC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1667
p.P118H	TCGA-BR-8078	STAD	TCGA	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2778
p.P118H	DO38288	STAD	ICGC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2778
p.D113N	TCGA-EO-A22X	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.D113N	DO43907	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.E129K	TCGA-IB-7651	PAAD	TCGA	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.E129K	DO46657	PAAD	ICGC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.L119F	DO234266	ESAD	ICGC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.K230T	DO233951	GACA	ICGC	AKENR	DEG_APCC_KENBOX_2	237:241	Mutation substituting flanking lysine	0.25
p.T123N	DO229022	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7055
p.E239K	DO220885	MELA	ICGC	AKENR	DEG_APCC_KENBOX_2	237:241	Mutation altering degron motif	0.7022
p.T147P	SIDM02039	Colorectal Carcinoma	GDSC	MKTPFST	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7031
p.G131E	SIDM00040	Gastric Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.G131E	TMK-1	stomach	COSMIC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1389
p.T124N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7055
p.T124N	ACH-002222	Leukemia	CCLE	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7055
p.T124N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7055
p.D159N	SIDM01504	Small Cell Lung Carcinoma	GDSC	MKTPFST	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.D159N	ACH-000594	Lung Cancer	CCLE	MKTPFST	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.P134T	ACH-001513	Cervical Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0556
p.M115T	ACH-001607	Gallbladder Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944

Kaplan plot for AUNIP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AUNIP

UniProt ID: Q9H7T9

Entrez ID: 79000

Protein name: Aurora kinase A and ninein-interacting protein (AIBp)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AUNIP in