DegronMD

Uniprot ID: Q9H7T9

Source protein: Aurora kinase A and ninein-interacting protein

Source gene: AUNIP

Class: DEG_SCF_FBW7_1

Location: 145:151

E3 ligase: FBXW7

DEGRON score: 0.7652

ASA_SCORE: 97.8714

COIL: 0.8644

CONS_SCORE: 0.3006

DSS_SCORE: 0.5778

HELIX: 0.08

FCONS_SCORE: 0.5658

RIG_SCORE: 0.6852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S140F	TCGA-A8-A09N	BRCA	TCGA	MKTPFST	DEG_SCF_FBW7_1	0.1944
p.S140F	DO5081	BRCA	ICGC	MKTPFST	DEG_SCF_FBW7_1	0.1944
p.T147P	SIDM02039	Colorectal Carcinoma	GDSC	MKTPFST	DEG_SCF_FBW7_1	0.7031
p.D159N	SIDM01504	Small Cell Lung Carcinoma	GDSC	MKTPFST	DEG_SCF_FBW7_1	0.1111
p.D159N	ACH-000594	Lung Cancer	CCLE	MKTPFST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SCF_FBW7_1	145:151	MKTPFST	FBXW7	0.7652	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons