DegronMD

Uniprot ID: Q9H7T9

Source protein: Aurora kinase A and ninein-interacting protein

Source gene: AUNIP

Class: DEG_SPOP_SBC_1

Location: 120:124

E3 ligase: SPOP

DEGRON score: 0.9953

ASA_SCORE: 73.78

COIL: 0.8222

CONS_SCORE: 0.6886

DSS_SCORE: 0.4754

HELIX: 0.1506

FCONS_SCORE: 1.2731

RIG_SCORE: 0.7141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A130V	TCGA-BH-A0HF	BRCA	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1667
p.A130V	DO1749	BRCA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.P118H	TCGA-BR-8078	STAD	TCGA	ATSTT	DEG_SPOP_SBC_1	0.2778
p.P118H	DO38288	STAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.2778
p.D113N	TCGA-EO-A22X	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1389
p.D113N	DO43907	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1389
p.E129K	TCGA-IB-7651	PAAD	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1944
p.E129K	DO46657	PAAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.L119F	DO234266	ESAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.T123N	DO229022	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7055
p.G131E	SIDM00040	Gastric Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.1389
p.G131E	TMK-1	stomach	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.1389
p.T124N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ATSTT	DEG_SPOP_SBC_1	0.7055
p.T124N	ACH-002222	Leukemia	CCLE	ATSTT	DEG_SPOP_SBC_1	0.7055
p.T124N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.7055
p.P134T	ACH-001513	Cervical Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.0556
p.M115T	ACH-001607	Gallbladder Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons