DegronMD

Uniprot ID: Q96KS0

Source protein: Prolyl hydroxylase EGLN2

Source gene: EGLN2

Class: DEG_SPOP_SBC_1

Location: 68:72

E3 ligase: SPOP

DEGRON score: 0.9971

ASA_SCORE: 70.78

COIL: 0.7746

CONS_SCORE: 0.3974

DSS_SCORE: 0.655

HELIX: 0.106

FCONS_SCORE: 1.0592

RIG_SCORE: 0.6717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R77W	TCGA-37-4133	LUSC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1944
p.R77W	TCGA-AP-A1DV	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1944
p.R77W	DO26465	LUSC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.R77W	DO43186	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.R77L	TCGA-66-2734	LUSC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1944
p.R77L	DO26430	LUSC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.A68T	TCGA-B5-A3FC	UCEC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.7139
p.A68T	DO41871	UCEC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7139
p.R77Q	TCGA-FD-A5C0	BLCA	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1944
p.R77Q	DO44046	BLCA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.R73W	DO12256	GBM	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.R73Q	DO229055	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.V78L	DO229009	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.Y82C	DO52187	LIHC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.0556
p.R64L	DO28923	OV	ICGC	ATSTT	DEG_SPOP_SBC_1	0.2222
p.T72N	SIDM00334	Endometrial Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.7055
p.T72N	ACH-000879	Endometrial/Uterine Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.7055
p.T72N	MFE-296	endometrium	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.7055
p.G79S	ACH-001061	Colon/Colorectal Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons