DegronMD

Uniprot ID: Q8N3K9

Source protein: Cardiomyopathy-associated protein 5

Source gene: CMYA5

Class: DEG_SPOP_SBC_1

Location: 3718:3722

E3 ligase: SPOP

DEGRON score: 0.6471

ASA_SCORE: 53.46

COIL: 0.6124

CONS_SCORE: 0.4947

DSS_SCORE: 0.4817

HELIX: 0.0816

FCONS_SCORE: 1.0738

RIG_SCORE: 0.7249

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y3726C	TCGA-13-1477	OV	TCGA	ATSTT	DEG_SPOP_SBC_1	0.2222
p.Y3726C	DO27978	OV	ICGC	ATSTT	DEG_SPOP_SBC_1	0.2222
p.T3721K	TCGA-22-1016	LUSC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.7306
p.T3721K	DO26971	LUSC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7306
p.T3722A	TCGA-55-1594	LUAD	TCGA	ATSTT	DEG_SPOP_SBC_1	0.7139
p.T3722A	DO24722	LUAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7139
p.S3717Y	TCGA-F5-6814	READ	TCGA	ATSTT	DEG_SPOP_SBC_1	0.3056
p.S3717Y	DO36556	READ	ICGC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.N3730S	TCGA-F7-A624	HNSC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1111
p.N3730S	DO44440	HNSC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1111
p.P3712S	DO234389	ESAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.P3712S	SIDM00944	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.P3712S	SIDM00453	Pancreatic Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.P3712S	SIDM00447	B-Lymphoblastic Leukemia	GDSC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.P3712S	SIDM01709	Melanoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.1667
p.A3724S	DO229038	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.2778
p.W3727C	DO51134	PRAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1944
p.P3708S	SIDM00499	Prostate Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.0556
p.P3708S	ACH-000956	Prostate Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.0556
p.P3708S	22RV1	prostate	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.0556
p.S3717F	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.S3717F	ACH-000837	Lung Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.3056
p.S3717F	NCI-H322M	lung	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.I3723T	SIDM01217	Other Blood Cancers	GDSC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.I3723T	ACH-002276	Leukemia	CCLE	ATSTT	DEG_SPOP_SBC_1	0.3056
p.I3723T	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSTT

Degron related mutations and impact score

Drug responses associated with CMYA5 mutations

All proteins holding degron of ATSTT