DegronMD

Uniprot ID: Q12830

Source protein: Nucleosome-remodeling factor subunit BPTF

Source gene: BPTF

Class: DEG_SPOP_SBC_1

Location: 2055:2059

E3 ligase: SPOP

DEGRON score: 0.9969

ASA_SCORE: 96.98

COIL: 0.9584

CONS_SCORE: 0.2637

DSS_SCORE: 0.5875

HELIX: 0.0148

FCONS_SCORE: 0.8881

RIG_SCORE: 0.6709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2058C	DO234336	ESAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.8301
p.S2047I	DO229041	LICA	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1111
p.R2058H	SIDM00193	Colorectal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.8244
p.R2058H	SNU-81	large_intestine	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.8244
p.K2050M	ACH-000879	Endometrial/Uterine Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.3056
p.K2050M	MFE-296	endometrium	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.3056
p.T2058S	SW1990	pancreas	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.7116
p.R2045H	SNU-81	large_intestine	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.0556
p.A2055T	NCI-H1155	lung	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons