DegronMD

Uniprot ID: P26651

Source protein: mRNA decay activator protein ZFP36

Source gene: ZFP36

Class: DEG_SPOP_SBC_1

Location: 96:100

E3 ligase: SPOP

DEGRON score: 0.8743

ASA_SCORE: 89.72

COIL: 0.939

CONS_SCORE: 0.5073

DSS_SCORE: 0.6175

HELIX: 0.0356

FCONS_SCORE: 0.8587

RIG_SCORE: 0.6349

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A102S	TCGA-34-2609	LUSC	TCGA	ATSTT	DEG_SPOP_SBC_1	0.2778
p.S108L	TCGA-MN-A4N1	LUAD	TCGA	ATSTT	DEG_SPOP_SBC_1	0.1111
p.S108L	DO45328	LUAD	ICGC	ATSTT	DEG_SPOP_SBC_1	0.1111
p.P87L	DO11854	GBM	ICGC	ATSTT	DEG_SPOP_SBC_1	0.0833
p.E92G	DO16999	KIRC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.6667
p.A96S	DO26981	LUSC	ICGC	ATSTT	DEG_SPOP_SBC_1	0.7588
p.S108W	SIDM01048	Plasma Cell Myeloma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.1111
p.S108W	ACH-000821	Myeloma	CCLE	ATSTT	DEG_SPOP_SBC_1	0.1111
p.S108W	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.1111
p.P95S	SIDM00222	Mesothelioma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.75
p.P95S	ACH-000319	Lung Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.75
p.P95S	MPP-89	pleura	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.75
p.A86D	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.0556
p.A86D	ACH-002254	Lymphoma	CCLE	ATSTT	DEG_SPOP_SBC_1	0.0556
p.A86D	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.0556
p.E92Q	SIDM00479	Esophageal Carcinoma	GDSC	ATSTT	DEG_SPOP_SBC_1	0.6667
p.E92Q	ACH-000679	Esophageal Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.6667
p.E92Q	OE19	oesophagus	COSMIC	ATSTT	DEG_SPOP_SBC_1	0.6667
p.L89P	ACH-001377	Pancreatic Cancer	CCLE	ATSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	227:231	ATSTT	SPOP	0.8403	More...
P26651	mRNA decay activator protein ZFP36	DEG_SPOP_SBC_1	96:100	ATSTT	SPOP	0.8743	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1173:1177	ATSTT	SPOP	0.9978	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2055:2059	ATSTT	SPOP	0.9969	More...
Q5T2D2	Trem-like transcript 2 protein	DEG_SPOP_SBC_1	194:198	ATSTT	SPOP	0.8687	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3486:3490	ATSTT	SPOP	0.9297	More...
Q8N3K9	Cardiomyopathy-associated protein 5	DEG_SPOP_SBC_1	3718:3722	ATSTT	SPOP	0.6471	More...
Q96KS0	Prolyl hydroxylase EGLN2	DEG_SPOP_SBC_1	68:72	ATSTT	SPOP	0.9971	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_SPOP_SBC_1	120:124	ATSTT	SPOP	0.9953	More...
Q9UHR5	SAP30-binding protein	DEG_SPOP_SBC_1	235:239	ATSTT	SPOP	0.6492	More...
Q12872	Splicing factor, suppressor of white-apricot homolog	DEG_SPOP_SBC_1	433:437	ATSTT	SPOP	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons