DegronMD

Uniprot ID: Q9H7T9

Source protein: Aurora kinase A and ninein-interacting protein

Source gene: AUNIP

Class: DEG_APCC_KENBOX_2

Location: 237:241

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8938

ASA_SCORE: 111.5

COIL: 0.6208

CONS_SCORE: 0.704

DSS_SCORE: 0.464

HELIX: 0.3656

FCONS_SCORE: 1.185

RIG_SCORE: 0.7408

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y250H	TCGA-AO-A128	BRCA	TCGA	AKENR	DEG_APCC_KENBOX_2	0.0833
p.Y250H	DO5326	BRCA	ICGC	AKENR	DEG_APCC_KENBOX_2	0.0833
p.G227C	TCGA-AX-A2HD	UCEC	TCGA	AKENR	DEG_APCC_KENBOX_2	0.0556
p.G227C	DO42608	UCEC	ICGC	AKENR	DEG_APCC_KENBOX_2	0.0556
p.K230T	DO233951	GACA	ICGC	AKENR	DEG_APCC_KENBOX_2	0.25
p.E239K	DO220885	MELA	ICGC	AKENR	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07492	Gastrin-releasing peptide	DEG_APCC_KENBOX_2	90:94	AKENR	APC,CDC20,FZR1	0.958	More...
Q03989	AT-rich interactive domain-containing protein 5A	DEG_APCC_KENBOX_2	166:170	AKENR	APC,CDC20,FZR1	0.9954	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_APCC_KENBOX_2	237:241	AKENR	APC,CDC20,FZR1	0.8938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons