DegronMD

Uniprot ID: Q03989

Source protein: AT-rich interactive domain-containing protein 5A

Source gene: ARID5A

Class: DEG_APCC_KENBOX_2

Location: 166:170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9954

ASA_SCORE: 120.2

COIL: 0.7164

CONS_SCORE: 0.4811

DSS_SCORE: 0.7346

HELIX: 0.2724

FCONS_SCORE: 1.1466

RIG_SCORE: 0.6129

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A164S	DO229034	LICA	ICGC	AKENR	DEG_APCC_KENBOX_2	0.2778
p.S160F	DO37441	SKCM	ICGC	AKENR	DEG_APCC_KENBOX_2	0.1667
p.R173Q	DO38192	STAD	ICGC	AKENR	DEG_APCC_KENBOX_2	0.25
p.F178L	DO43755	UCEC	ICGC	AKENR	DEG_APCC_KENBOX_2	0.1111
p.S157Y	DO42665	UCEC	ICGC	AKENR	DEG_APCC_KENBOX_2	0.0833
p.K180T	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENR	DEG_APCC_KENBOX_2	0.1667
p.E177K	SIDM00253	Neuroblastoma	GDSC	AKENR	DEG_APCC_KENBOX_2	0.1389
p.V162E	ACH-000992	Head and Neck Cancer	CCLE	AKENR	DEG_APCC_KENBOX_2	0.2222
p.G166S	ACH-000995	Leukemia	CCLE	AKENR	DEG_APCC_KENBOX_2	0.6993
p.G166S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	AKENR	DEG_APCC_KENBOX_2	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07492	Gastrin-releasing peptide	DEG_APCC_KENBOX_2	90:94	AKENR	APC,CDC20,FZR1	0.958	More...
Q03989	AT-rich interactive domain-containing protein 5A	DEG_APCC_KENBOX_2	166:170	AKENR	APC,CDC20,FZR1	0.9954	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_APCC_KENBOX_2	237:241	AKENR	APC,CDC20,FZR1	0.8938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons