DegronMD

Uniprot ID: P07492

Source protein: Gastrin-releasing peptide

Source gene: GRP

Class: DEG_APCC_KENBOX_2

Location: 90:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.958

ASA_SCORE: 103.08

COIL: 0.6984

CONS_SCORE: 0.495

DSS_SCORE: 0.5952

HELIX: 0.2854

FCONS_SCORE: 0.9983

RIG_SCORE: 0.6683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L104M	TCGA-AX-A06F	UCEC	TCGA	AKENR	DEG_APCC_KENBOX_2	0.0556
p.L104M	TCGA-BR-8487	STAD	TCGA	AKENR	DEG_APCC_KENBOX_2	0.0556
p.L104M	DO47867	STAD	ICGC	AKENR	DEG_APCC_KENBOX_2	0.0556
p.L104M	DO41752	UCEC	ICGC	AKENR	DEG_APCC_KENBOX_2	0.0556
p.E92V	TCGA-BF-A5ES	SKCM	TCGA	AKENR	DEG_APCC_KENBOX_2	0.7693
p.E92V	DO219456	SKCM	ICGC	AKENR	DEG_APCC_KENBOX_2	0.7693
p.P101T	TCGA-CA-6717	COAD	TCGA	AKENR	DEG_APCC_KENBOX_2	0.1389
p.P101T	DO8264	COAD	ICGC	AKENR	DEG_APCC_KENBOX_2	0.1389
p.P101L	TCGA-FS-A1ZP	SKCM	TCGA	AKENR	DEG_APCC_KENBOX_2	0.1389
p.P101L	DO37703	SKCM	ICGC	AKENR	DEG_APCC_KENBOX_2	0.1389
p.E92Q	TCGA-KQ-A41O	BLCA	TCGA	AKENR	DEG_APCC_KENBOX_2	0.6744
p.E92Q	DO223589	BLCA	ICGC	AKENR	DEG_APCC_KENBOX_2	0.6744
p.R94I	DO222884	COCA	ICGC	AKENR	DEG_APCC_KENBOX_2	0.6991
p.A90G	DO222557	MELA	ICGC	AKENR	DEG_APCC_KENBOX_2	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07492	Gastrin-releasing peptide	DEG_APCC_KENBOX_2	90:94	AKENR	APC,CDC20,FZR1	0.958	More...
Q03989	AT-rich interactive domain-containing protein 5A	DEG_APCC_KENBOX_2	166:170	AKENR	APC,CDC20,FZR1	0.9954	More...
Q9H7T9	Aurora kinase A and ninein-interacting protein	DEG_APCC_KENBOX_2	237:241	AKENR	APC,CDC20,FZR1	0.8938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons