DegronMD - P07492(GRP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L104M	TCGA-AX-A06F	UCEC	TCGA	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.L104M	TCGA-BR-8487	STAD	TCGA	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.L104M	DO47867	STAD	ICGC	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.L104M	DO41752	UCEC	ICGC	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.E92V	TCGA-BF-A5ES	SKCM	TCGA	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.7693
p.E92V	DO219456	SKCM	ICGC	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.7693
p.P101T	TCGA-CA-6717	COAD	TCGA	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.P101T	DO8264	COAD	ICGC	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.L87F	TCGA-CG-4465	STAD	TCGA	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation altering degron motif	0.587
p.L87F	DO38627	STAD	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation altering degron motif	0.587
p.L87P	TCGA-DX-AB30	SARC	TCGA	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation altering degron motif	0.6471
p.L87P	DO220100	SARC	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation altering degron motif	0.6471
p.P101L	TCGA-FS-A1ZP	SKCM	TCGA	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.P101L	DO37703	SKCM	ICGC	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.E73Q	TCGA-KQ-A41O	BLCA	TCGA	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation rewiring degron network	0.1111
p.E73Q	DO223589	BLCA	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation rewiring degron network	0.1111
p.E92Q	TCGA-KQ-A41O	BLCA	TCGA	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6744
p.E92Q	DO223589	BLCA	ICGC	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6744
p.L84F	TCGA-X9-A971	SARC	TCGA	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation altering degron motif	0.587
p.L84F	DO220327	SARC	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation altering degron motif	0.587
p.R94I	DO222884	COCA	ICGC	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6991
p.R76S	DO228974	LICA	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation rewiring degron network	0.1944
p.R82K	DO222402	MELA	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation altering degron motif	0.7237
p.A90G	DO222557	MELA	ICGC	AKENR	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6429
p.G86S	DO232044	ORCA	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	81:89	Mutation altering degron motif	0.5882

Kaplan plot for GRP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRP

UniProt ID: P07492

Entrez ID: 2922

Protein name: Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10) (GRP18-27)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRP in