DegronMD

Uniprot ID: P07492

Source protein: Gastrin-releasing peptide

Source gene: GRP

Class: DEG_APCC_DBOX_1

Location: 81:89

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5138

ASA_SCORE: 49.9667

COIL: 0.1572

CONS_SCORE: 0.5819

DSS_SCORE: 0.3656

HELIX: 0.8366

FCONS_SCORE: 1.1949

RIG_SCORE: 0.7836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L87F	TCGA-CG-4465	STAD	TCGA	ARNLLGLIE	DEG_APCC_DBOX_1	0.587
p.L87F	DO38627	STAD	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	0.587
p.L87P	TCGA-DX-AB30	SARC	TCGA	ARNLLGLIE	DEG_APCC_DBOX_1	0.6471
p.L87P	DO220100	SARC	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	0.6471
p.E73Q	TCGA-KQ-A41O	BLCA	TCGA	ARNLLGLIE	DEG_APCC_DBOX_1	0.1111
p.E73Q	DO223589	BLCA	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	0.1111
p.L84F	TCGA-X9-A971	SARC	TCGA	ARNLLGLIE	DEG_APCC_DBOX_1	0.587
p.L84F	DO220327	SARC	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	0.587
p.R76S	DO228974	LICA	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	0.1944
p.R82K	DO222402	MELA	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	0.7237
p.G86S	DO232044	ORCA	ICGC	ARNLLGLIE	DEG_APCC_DBOX_1	0.5882

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P07492	Gastrin-releasing peptide	DEG_APCC_DBOX_1	81:89	ARNLLGLIE	APC,CDC20,FZR1	0.5138	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons