DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RKENK
Uniprot ID:
Q7Z6Z7
Source protein:
E3 ubiquitin-protein ligase HUWE1
Source gene:
HUWE1
Class:
DEG_APCC_KENBOX_2
Location:
1714:1718
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9828
ASA_SCORE:
125.3
COIL:
0.587
CONS_SCORE:
0.3246
DSS_SCORE:
0.5968
HELIX:
0.4006
FCONS_SCORE:
1.0193
RIG_SCORE:
0.6467
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1707N
TCGA-AX-A2HC
UCEC
TCGA
RKENK
DEG_APCC_KENBOX_2
0.5833
p.S1707N
DO41572
UCEC
ICGC
RKENK
DEG_APCC_KENBOX_2
0.5833
p.G1719D
TCGA-B5-A1MR
UCEC
TCGA
RKENK
DEG_APCC_KENBOX_2
0.3056
p.G1719D
DO41758
UCEC
ICGC
RKENK
DEG_APCC_KENBOX_2
0.3056
p.P1723L
TCGA-B5-A1MX
UCEC
TCGA
RKENK
DEG_APCC_KENBOX_2
0.1944
p.P1723L
TCGA-FW-A3R5
SKCM
TCGA
RKENK
DEG_APCC_KENBOX_2
0.1944
p.P1723L
DO37406
SKCM
ICGC
RKENK
DEG_APCC_KENBOX_2
0.1944
p.P1723L
DO41999
UCEC
ICGC
RKENK
DEG_APCC_KENBOX_2
0.1944
p.A1725V
TCGA-EY-A1GU
UCEC
TCGA
RKENK
DEG_APCC_KENBOX_2
0.1389
p.A1725V
DO41518
UCEC
ICGC
RKENK
DEG_APCC_KENBOX_2
0.1389
p.K1713E
TCGA-G4-6302
COAD
TCGA
RKENK
DEG_APCC_KENBOX_2
0.75
p.K1713E
DO8778
COAD
ICGC
RKENK
DEG_APCC_KENBOX_2
0.75
p.S1707R
DO1235
BRCA
ICGC
RKENK
DEG_APCC_KENBOX_2
0.5833
p.R1714H
DO228946
LICA
ICGC
RKENK
DEG_APCC_KENBOX_2
0.7133
Drug responses associated with HUWE1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RKENK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
DEG_APCC_KENBOX_2
1714:1718
RKENK
APC,CDC20,FZR1
0.9828
More...