DegronMD

Uniprot ID: Q7Z6Z7

Source protein: E3 ubiquitin-protein ligase HUWE1

Source gene: HUWE1

Class: DEG_SPOP_SBC_1

Location: 1087:1091

E3 ligase: SPOP

DEGRON score: 0.5559

ASA_SCORE: 85.78

COIL: 0.8932

CONS_SCORE: 0.3093

DSS_SCORE: 0.657

HELIX: 0.1002

FCONS_SCORE: 0.8337

RIG_SCORE: 0.6552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1096S	TCGA-90-A59Q	LUSC	TCGA	AASTT	DEG_SPOP_SBC_1	0.1944
p.P1096S	DO50103	LUSC	ICGC	AASTT	DEG_SPOP_SBC_1	0.1944
p.A1088T	TCGA-A5-A0G1	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	0.6028
p.A1088T	DO42472	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	0.6028
p.A1098V	TCGA-AU-6004	COAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.1389
p.A1098V	DO7780	COAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.1389
p.V1079F	TCGA-BR-A4PD	STAD	TCGA	AASTT	DEG_SPOP_SBC_1	0.1111
p.V1079F	DO47831	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.1111
p.P1094Q	TCGA-EE-A2MD	SKCM	TCGA	AASTT	DEG_SPOP_SBC_1	0.25
p.P1094Q	DO37851	SKCM	ICGC	AASTT	DEG_SPOP_SBC_1	0.25
p.S1084N	DO222718	COCA	ICGC	AASTT	DEG_SPOP_SBC_1	0.6944
p.S1084G	DO50398	ESAD	ICGC	AASTT	DEG_SPOP_SBC_1	0.6944
p.A1098T	DO233151	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	0.1389
p.A1093E	DO228948	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	0.2778
p.Q1081K	DO229015	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	0.1667
p.H1086N	DO229045	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	0.3056
p.S1084R	DO229009	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	0.6944
p.A1098S	DO50893	LICA	ICGC	AASTT	DEG_SPOP_SBC_1	0.1389
p.R1080H	DO229257	THCA	ICGC	AASTT	DEG_SPOP_SBC_1	0.1389
p.R1083S	SIDM00772	Breast Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	0.2222
p.R1083S	ACH-000755	Breast Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	0.2222
p.R1083S	HCC2218	breast	COSMIC	AASTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8K4G0	CMRF35-like molecule 7	DEG_SPOP_SBC_1	126:130	AASTT	SPOP	0.5335	More...
O00592	Podocalyxin	DEG_SPOP_SBC_1	320:324	AASTT	SPOP	0.9973	More...
O14974	Protein phosphatase 1 regulatory subunit 12A	DEG_SPOP_SBC_1	642:646	AASTT	SPOP	0.9917	More...
P28356	Homeobox protein Hox-D9	DEG_SPOP_SBC_1	173:177	AASTT	SPOP	0.9609	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	237:241	AASTT	SPOP	0.7405	More...
Q02086	Transcription factor Sp2	DEG_SPOP_SBC_1	23:27	AASTT	SPOP	0.9884	More...
Q5JR59	Microtubule-associated tumor suppressor candidate 2	DEG_SPOP_SBC_1	959:963	AASTT	SPOP	0.869	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	2203:2207	AASTT	SPOP	0.7885	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1974:1978	AASTT	SPOP	0.5287	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	1087:1091	AASTT	SPOP	0.5559	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3497:3501	AASTT	SPOP	0.9452	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3529:3533	AASTT	SPOP	0.6297	More...
Q96DR8	Mucin-like protein 1	DEG_SPOP_SBC_1	64:68	AASTT	SPOP	0.9933	More...
Q9Y4G6	Talin-2	DEG_SPOP_SBC_1	1141:1145	AASTT	SPOP	0.6347	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	225:229	AASTT	SPOP	0.9923	More...
Q53QW1	Testis-expressed protein 44	DEG_SPOP_SBC_1	186:190	AASTT	SPOP	0.8941	More...
Q6UXI7	Vitrin	DEG_SPOP_SBC_1	207:211	AASTT	SPOP	0.5243	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	449:453	AASTT	SPOP	0.9591	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	418:422	AASTT	SPOP	0.9307	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	537:541	AASTT	SPOP	0.7877	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1527:1531	AASTT	SPOP	0.6149	More...
Q9NRJ2	Putative uncharacterized protein GSN-AS1	DEG_SPOP_SBC_1	133:137	AASTT	SPOP	0.9628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASTT

Degron related mutations and impact score

Drug responses associated with HUWE1 mutations

All proteins holding degron of AASTT