DegronMD - P55318(FOXA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P281H	TCGA-66-2727	LUSC	TCGA	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.3056
p.P281H	DO26478	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.3056
p.G233R	TCGA-AA-3821	COAD	TCGA	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.G233R	TCGA-AA-3821	COAD	TCGA	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.G233R	DO9314	COAD	ICGC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.G233R	DO9314	COAD	ICGC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.F283L	TCGA-AN-A046	BRCA	TCGA	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.F283L	DO1285	BRCA	ICGC	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.S224I	TCGA-AP-A059	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.S224I	DO41361	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.T280A	TCGA-BR-4292	STAD	TCGA	PASST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.T280A	DO38495	STAD	ICGC	PASST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7139
p.G222E	TCGA-BR-6452	STAD	TCGA	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.G222E	DO38404	STAD	ICGC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.S26L	TCGA-CG-4305	STAD	TCGA	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation rewiring degron network	0.3056
p.S26L	DO38823	STAD	ICGC	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation rewiring degron network	0.3056
p.A270V	TCGA-D3-A8GI	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.A270V	DO50284	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.A244T	TCGA-GS-A9TT	DLBC	TCGA	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.25
p.A244T	DO219912	DLBC	ICGC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.25
p.A244T	ACH-001719	Ovarian Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.25
p.S279Y	TCGA-HE-7130	KIRP	TCGA	PASST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.712
p.S279Y	DO20776	KIRP	ICGC	PASST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.712
p.G290E	TCGA-HF-7132	STAD	TCGA	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.G290E	DO38214	STAD	ICGC	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.G235R	TCGA-XK-AAIW	PRAD	TCGA	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1944
p.G235R	TCGA-XK-AAIW	PRAD	TCGA	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.G235R	DO51407	PRAD	ICGC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1944
p.G235R	DO51407	PRAD	ICGC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.G223D	DO233168	GACA	ICGC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.G223D	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.G223D	ACH-000980	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.G223D	NCI-H1155	lung	COSMIC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.P250L	DO233766	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.0833
p.V28L	DO228952	LICA	ICGC	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation altering degron motif	0.5654
p.N232S	DO222644	MELA	ICGC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2778
p.N232S	DO222644	MELA	ICGC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1944
p.V28M	DO222868	MELA	ICGC	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation altering degron motif	0.6097
p.V28M	SIDM00976	Melanoma	GDSC	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation altering degron motif	0.6097
p.V28M	ACH-002205	Skin Cancer	CCLE	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation altering degron motif	0.6097
p.E217K	DO222887	MELA	ICGC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.0833
p.T242P	DO218914	SKCA	ICGC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.3056
p.A245T	SIDM02035	Colorectal Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2222
p.M41I	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation rewiring degron network	0.1111
p.M41I	ACH-002243	Esophageal Cancer	CCLE	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation rewiring degron network	0.1111
p.M41I	HCE-4	oesophagus	COSMIC	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation rewiring degron network	0.1111
p.G274A	SIDM00871	Non-Cancerous	GDSC	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.G274A	SIDM00872	Breast Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.G274A	ACH-000859	Breast Cancer	CCLE	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.G274A	ACH-002384	Non-Cancerous	CCLE	PASST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.G235V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1944
p.G235V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.G235V	ACH-000951	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1944
p.G235V	ACH-000951	Lung Cancer	CCLE	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.2778
p.T248N	SIDM00431	T-Lymphoblastic Leukemia	GDSC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389
p.T248N	SIDM00736	Non-Cancerous	GDSC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389
p.T248N	SIDM00720	Mesothelioma	GDSC	AASTT	DEG_SPOP_SBC_1	237:241	Mutation rewiring degron network	0.1389
p.A35T	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation rewiring degron network	0.2778
p.A35T	ACH-000937	Leukemia	CCLE	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation rewiring degron network	0.2778
p.A35T	PF-382	haematopoietic and lymphoid tissue	COSMIC	PVTPVPT	DEG_SCF_FBW7_1	27:33	Mutation rewiring degron network	0.2778
p.P276A	SIDM00150	Colorectal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.6392

Kaplan plot for FOXA3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXA3

UniProt ID: P55318

Entrez ID: 3171

Protein name: Hepatocyte nuclear factor 3-gamma (HNF-3-gamma) (HNF-3G) (Fork head-related protein FKH H3) (Forkhead box protein A3) (Transcription factor 3G) (TCF-3G)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXA3 in