DegronMD

Uniprot ID: P55318

Source protein: Hepatocyte nuclear factor 3-gamma

Source gene: FOXA3

Class: DEG_SCF_FBW7_1

Location: 27:33

E3 ligase: FBXW7

DEGRON score: 0.767

ASA_SCORE: 58.0143

COIL: 0.8989

CONS_SCORE: 0.3455

DSS_SCORE: 0.2773

HELIX: 0.0331

FCONS_SCORE: 1.0239

RIG_SCORE: 0.7561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S26L	TCGA-CG-4305	STAD	TCGA	PVTPVPT	DEG_SCF_FBW7_1	0.3056
p.S26L	DO38823	STAD	ICGC	PVTPVPT	DEG_SCF_FBW7_1	0.3056
p.V28L	DO228952	LICA	ICGC	PVTPVPT	DEG_SCF_FBW7_1	0.5654
p.V28M	DO222868	MELA	ICGC	PVTPVPT	DEG_SCF_FBW7_1	0.6097
p.V28M	SIDM00976	Melanoma	GDSC	PVTPVPT	DEG_SCF_FBW7_1	0.6097
p.V28M	ACH-002205	Skin Cancer	CCLE	PVTPVPT	DEG_SCF_FBW7_1	0.6097
p.M41I	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PVTPVPT	DEG_SCF_FBW7_1	0.1111
p.M41I	ACH-002243	Esophageal Cancer	CCLE	PVTPVPT	DEG_SCF_FBW7_1	0.1111
p.M41I	HCE-4	oesophagus	COSMIC	PVTPVPT	DEG_SCF_FBW7_1	0.1111
p.A35T	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PVTPVPT	DEG_SCF_FBW7_1	0.2778
p.A35T	ACH-000937	Leukemia	CCLE	PVTPVPT	DEG_SCF_FBW7_1	0.2778
p.A35T	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PVTPVPT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SCF_FBW7_1	27:33	PVTPVPT	FBXW7	0.767	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons