DegronMD

Uniprot ID: P55318

Source protein: Hepatocyte nuclear factor 3-gamma

Source gene: FOXA3

Class: DEG_SPOP_SBC_1

Location: 226:230

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 71.6

COIL: 0.8308

CONS_SCORE: 0.3938

DSS_SCORE: 0.6461

HELIX: 0.08

FCONS_SCORE: 1.1123

RIG_SCORE: 0.6516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G233R	TCGA-AA-3821	COAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.25
p.G233R	DO9314	COAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.25
p.S224I	TCGA-AP-A059	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.2778
p.S224I	DO41361	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.2778
p.G222E	TCGA-BR-6452	STAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.2222
p.G222E	DO38404	STAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.2222
p.G235R	TCGA-XK-AAIW	PRAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.1944
p.G235R	DO51407	PRAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.1944
p.G223D	DO233168	GACA	ICGC	AATTT	DEG_SPOP_SBC_1	0.25
p.G223D	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.25
p.G223D	ACH-000980	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.25
p.G223D	NCI-H1155	lung	COSMIC	AATTT	DEG_SPOP_SBC_1	0.25
p.N232S	DO222644	MELA	ICGC	AATTT	DEG_SPOP_SBC_1	0.2778
p.E217K	DO222887	MELA	ICGC	AATTT	DEG_SPOP_SBC_1	0.0833
p.G235V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.1944
p.G235V	ACH-000951	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons