DegronMD - Q8WY41(NANOS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E107D	DO4155	BRCA	ICGC	PPDY	ITCH	102:105	Mutation rewiring degron network	0.2778
p.E178K	DO222617	BTCA	ICGC	AATTT	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2778
p.A173T	DO222877	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	172:176	Mutation altering degron motif	0.6028
p.A173T	DO233855	GACA	ICGC	AATTT	DEG_SPOP_SBC_1	172:176	Mutation altering degron motif	0.6028
p.P98S	DO229227	THCA	ICGC	PPDY	ITCH	102:105	Mutation rewiring degron network	0.2222
p.G71S	SIDM00094	Kidney Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1944
p.A168T	SIDM00498	Colorectal Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.G68D	SIDM00032	Bladder Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1111
p.G68D	ACH-000839	Bladder Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1111
p.C85Y	ACH-000280	Ovarian Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1944
p.R280H	ACH-000941	Endometrial/Uterine Cancer	CCLE	KLR	DEG_APCC_TPR_1	290:292	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons