DegronMD

Uniprot ID: Q96N19

Source protein: Integral membrane protein GPR137

Source gene: GPR137

Class: DEG_SPOP_SBC_1

Location: 349:353

E3 ligase: SPOP

DEGRON score: 0.882

ASA_SCORE: 59.2

COIL: 0.8384

CONS_SCORE: 0.3199

DSS_SCORE: 0.6973

HELIX: 0.0824

FCONS_SCORE: 0.9438

RIG_SCORE: 0.6261

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R357W	TCGA-2Y-A9H9	LIHC	TCGA	AATTT	DEG_SPOP_SBC_1	0.2222
p.R357W	SIDM01470	Acute Myeloid Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.R357W	ACH-000387	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	0.2222
p.R357L	TCGA-50-5045	LUAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.2222
p.V340M	TCGA-A5-A0G2	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.0833
p.V340M	SIDM01649	Non-Cancerous	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.V340M	SIDM01098	Neuroblastoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.V340M	SIDM00184	Melanoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.V340M	ACH-000149	Neuroblastoma	CCLE	AATTT	DEG_SPOP_SBC_1	0.0833
p.V340M	ACH-001188	Neuroblastoma	CCLE	AATTT	DEG_SPOP_SBC_1	0.0833
p.V340M	ACH-002355	Non-Cancerous	CCLE	AATTT	DEG_SPOP_SBC_1	0.0833
p.P359S	TCGA-DA-A95Z	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	0.1667
p.T346M	DO36839	READ	ICGC	AATTT	DEG_SPOP_SBC_1	0.25
p.P363S	DO37406	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.T343P	DO51238	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	0.1667
p.T343I	DO51238	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	0.1667
p.S346L	SIDM01191	Osteosarcoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.25
p.S346L	SIDM00123	Kidney Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.25
p.S346L	ACHN	kidney	COSMIC	AATTT	DEG_SPOP_SBC_1	0.25
p.S346L	U-2-OS	bone	COSMIC	AATTT	DEG_SPOP_SBC_1	0.25
p.R354Q	SIDM01086	B-Lymphoblastic Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	0.3056
p.R354Q	ACH-000874	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	0.3056
p.R354Q	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.3056
p.P363L	KP-3	pancreas	COSMIC	AATTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons