DegronMD

Uniprot ID: Q9HCJ2

Source protein: Leucine-rich repeat-containing protein 4C

Source gene: LRRC4C

Class: DEG_SPOP_SBC_1

Location: 445:449

E3 ligase: SPOP

DEGRON score: 0.8689

ASA_SCORE: 67.66

COIL: 0.8258

CONS_SCORE: 0.5924

DSS_SCORE: 0.2302

HELIX: 0.0086

FCONS_SCORE: 0.996

RIG_SCORE: 0.8036

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A445S	TCGA-12-3644	GBM	TCGA	AATTT	DEG_SPOP_SBC_1	0.7588
p.A445S	DO11735	GBM	ICGC	AATTT	DEG_SPOP_SBC_1	0.7588
p.S455L	TCGA-56-8625	LUSC	TCGA	AATTT	DEG_SPOP_SBC_1	0.1667
p.S455L	DO45515	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1667
p.S452F	TCGA-95-7567	LUAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.25
p.S452F	DO25564	LUAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.25
p.A439V	TCGA-BS-A0TE	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.1667
p.A439V	DO43506	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1667
p.V457I	TCGA-ER-A3EV	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	TCGA-EY-A215	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	DO48597	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	DO42665	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	SIDM01113	Other Sarcomas	GDSC	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	SIDM00833	Colorectal Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	ACH-000421	Colon/Colorectal Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	ACH-000939	Sarcoma	CCLE	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	ACH-001848	Bile Duct Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	SW837	large_intestine	COSMIC	AATTT	DEG_SPOP_SBC_1	0.1111
p.V457I	SK-UT-1	soft_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.1111
p.T448I	TCGA-OR-A5JB	ACC	TCGA	AATTT	DEG_SPOP_SBC_1	0.7078
p.T448I	DO222529	ESCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.7078
p.T448N	TCGA-WE-A8K4	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	0.7055
p.T448N	DO51281	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	0.7055
p.T448N	ACH-000870	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.7055
p.P450H	DO222503	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.P450H	DO233088	GACA	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.P450H	DO228976	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.F451L	DO222762	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.2778
p.F451L	DO222405	MELA	ICGC	AATTT	DEG_SPOP_SBC_1	0.2778
p.A437S	DO230976	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1111
p.A437S	DO224626	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1111
p.T449I	DO231155	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	0.7078
p.P450S	DO218863	SKCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.A446V	SIDM00994	T-Lymphoblastic Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	0.5825
p.A446V	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.5825
p.T444S	SIDM01218	Other Solid Cancers	GDSC	AATTT	DEG_SPOP_SBC_1	0.3056
p.T444S	ACH-001530	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.3056
p.T444S	JEG-3	placenta	COSMIC	AATTT	DEG_SPOP_SBC_1	0.3056
p.S452C	SIDM00631	Breast Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.25
p.S452C	ACH-001358	Breast Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.25
p.S452C	MDA-MB-330	breast	COSMIC	AATTT	DEG_SPOP_SBC_1	0.25
p.T447N	SIDM00294	Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.7055
p.T447N	ACH-001549	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.7055
p.T447N	LU-135	lung	COSMIC	AATTT	DEG_SPOP_SBC_1	0.7055
p.A439T	SIDM00901	Endometrial Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.1667
p.A439T	ACH-000940	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.1667
p.A439T	AN3-CA	endometrium	COSMIC	AATTT	DEG_SPOP_SBC_1	0.1667
p.P450R	SIDM01766	Chondrosarcoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.3056
p.P450R	ACH-000418	Bone Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.3056
p.T458I	SIDM00500	Colorectal Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.T458I	ACH-000959	Colon/Colorectal Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATTT

Degron related mutations and impact score

Drug responses associated with LRRC4C mutations

All proteins holding degron of AATTT