DegronMD - Q9HCJ2(LRRC4C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A445S	TCGA-12-3644	GBM	TCGA	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7588
p.A445S	DO11735	GBM	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7588
p.S455L	TCGA-56-8625	LUSC	TCGA	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.S455L	DO45515	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.S452F	TCGA-95-7567	LUAD	TCGA	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.S452F	DO25564	LUAD	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.A439V	TCGA-BS-A0TE	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.A439V	DO43506	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.V457I	TCGA-ER-A3EV	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	TCGA-EY-A215	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	DO48597	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	DO42665	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	SIDM01113	Other Sarcomas	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	SIDM00833	Colorectal Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	ACH-000421	Colon/Colorectal Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	ACH-000939	Sarcoma	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	ACH-001848	Bile Duct Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	SW837	large intestine	COSMIC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.V457I	SK-UT-1	soft tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.T448I	TCGA-OR-A5JB	ACC	TCGA	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7078
p.T448I	DO222529	ESCA	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7078
p.T448N	TCGA-WE-A8K4	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7055
p.T448N	DO51281	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7055
p.T448N	ACH-000870	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7055
p.P450H	DO222503	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.P450H	DO233088	GACA	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.P450H	DO228976	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.F451L	DO222762	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.2778
p.F451L	DO222405	MELA	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.2778
p.A437S	DO230976	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.A437S	DO224626	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1111
p.T449I	DO231155	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7078
p.P450S	DO218863	SKCA	ICGC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.A446V	SIDM00994	T-Lymphoblastic Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.5825
p.A446V	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.5825
p.T444S	SIDM01218	Other Solid Cancers	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.T444S	ACH-001530	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.T444S	JEG-3	placenta	COSMIC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.S452C	SIDM00631	Breast Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.S452C	ACH-001358	Breast Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.S452C	MDA-MB-330	breast	COSMIC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.25
p.T447N	SIDM00294	Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7055
p.T447N	ACH-001549	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7055
p.T447N	LU-135	lung	COSMIC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation altering degron motif	0.7055
p.A439T	SIDM00901	Endometrial Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.A439T	ACH-000940	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.A439T	AN3-CA	endometrium	COSMIC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.1667
p.P450R	SIDM01766	Chondrosarcoma	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.P450R	ACH-000418	Bone Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.3056
p.T458I	SIDM00500	Colorectal Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.0833
p.T458I	ACH-000959	Colon/Colorectal Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	445:449	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC4C

UniProt ID: Q9HCJ2

Entrez ID: 57689

Protein name: Leucine-rich repeat-containing protein 4C (Netrin-G1 ligand) (NGL-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC4C in