DegronMD - Q96N19(GPR137)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R357W	TCGA-2Y-A9H9	LIHC	TCGA	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.2222
p.R357W	SIDM01470	Acute Myeloid Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.2222
p.R357W	ACH-000387	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.2222
p.R357L	TCGA-50-5045	LUAD	TCGA	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.2222
p.V340M	TCGA-A5-A0G2	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0833
p.V340M	SIDM01649	Non-Cancerous	GDSC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0833
p.V340M	SIDM01098	Neuroblastoma	GDSC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0833
p.V340M	SIDM00184	Melanoma	GDSC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0833
p.V340M	ACH-000149	Neuroblastoma	CCLE	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0833
p.V340M	ACH-001188	Neuroblastoma	CCLE	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0833
p.V340M	ACH-002355	Non-Cancerous	CCLE	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0833
p.P416S	TCGA-BF-A3DL	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	408:417	Mutation altering degron motif	0.6752
p.P425L	TCGA-DA-A1I7	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.1111
p.P359S	TCGA-DA-A95Z	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.P423S	TCGA-EE-A29E	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.1667
p.P423S	TCGA-EE-A3JB	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.1667
p.P423L	TCGA-EE-A3JB	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.1667
p.R419C	TCGA-F5-6864	READ	TCGA	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.2778
p.P421S	TCGA-FW-A3R5	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.2222
p.P415L	DO902	BOCA	ICGC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation altering degron motif	0.7582
p.P415L	DO230334	COCA	ICGC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation altering degron motif	0.7582
p.P415L	DO42280	UCEC	ICGC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation altering degron motif	0.7582
p.P415L	SNU-1040	large intestine	COSMIC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation altering degron motif	0.7582
p.P403L	DO9514	COAD	ICGC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.1944
p.T346M	DO36839	READ	ICGC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.P417L	DO37567	SKCM	ICGC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation altering degron motif	0.6471
p.P405L	DO37819	SKCM	ICGC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.25
p.P405S	DO37410	SKCM	ICGC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.25
p.P363S	DO37406	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0556
p.T343P	DO51238	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.T343I	DO51238	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.L400F	DO38427	STAD	ICGC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.1111
p.P421L	SIDM00571	Pancreatic Carcinoma	GDSC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.2222
p.P421L	ACH-000108	Pancreatic Cancer	CCLE	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.2222
p.P421L	KP-3	pancreas	COSMIC	SCHSELVPSP	DEG_COP1_1	408:417	Mutation rewiring degron network	0.2222
p.S346L	SIDM01191	Osteosarcoma	GDSC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.S346L	SIDM00123	Kidney Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.S346L	ACHN	kidney	COSMIC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.S346L	U-2-OS	bone	COSMIC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.R354Q	SIDM01086	B-Lymphoblastic Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.3056
p.R354Q	ACH-000874	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.3056
p.R354Q	RS4-11	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.3056
p.P363L	KP-3	pancreas	COSMIC	AATTT	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0556

Kaplan plot for GPR137 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPR137

UniProt ID: Q96N19

Entrez ID: 56834

Protein name: Integral membrane protein GPR137 (Transmembrane 7 superfamily member 1-like 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPR137 in