DegronMD

Uniprot ID: Q96N19

Source protein: Integral membrane protein GPR137

Source gene: GPR137

Class: DEG_COP1_1

Location: 408:417

E3 ligase: COP1

DEGRON score: 0.9776

ASA_SCORE: 86.34

COIL: 0.8074

CONS_SCORE: 0.2841

DSS_SCORE: 0.2894

HELIX: 0.118

FCONS_SCORE: 1.6091

RIG_SCORE: 0.7287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P416S	TCGA-BF-A3DL	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	0.6752
p.P425L	TCGA-DA-A1I7	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	0.1111
p.P423S	TCGA-EE-A29E	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	0.1667
p.P423S	TCGA-EE-A3JB	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	0.1667
p.P423L	TCGA-EE-A3JB	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	0.1667
p.R419C	TCGA-F5-6864	READ	TCGA	SCHSELVPSP	DEG_COP1_1	0.2778
p.P421S	TCGA-FW-A3R5	SKCM	TCGA	SCHSELVPSP	DEG_COP1_1	0.2222
p.P415L	DO902	BOCA	ICGC	SCHSELVPSP	DEG_COP1_1	0.7582
p.P415L	DO230334	COCA	ICGC	SCHSELVPSP	DEG_COP1_1	0.7582
p.P415L	DO42280	UCEC	ICGC	SCHSELVPSP	DEG_COP1_1	0.7582
p.P415L	SNU-1040	large_intestine	COSMIC	SCHSELVPSP	DEG_COP1_1	0.7582
p.P403L	DO9514	COAD	ICGC	SCHSELVPSP	DEG_COP1_1	0.1944
p.P417L	DO37567	SKCM	ICGC	SCHSELVPSP	DEG_COP1_1	0.6471
p.P405L	DO37819	SKCM	ICGC	SCHSELVPSP	DEG_COP1_1	0.25
p.P405S	DO37410	SKCM	ICGC	SCHSELVPSP	DEG_COP1_1	0.25
p.L400F	DO38427	STAD	ICGC	SCHSELVPSP	DEG_COP1_1	0.1111
p.P421L	SIDM00571	Pancreatic Carcinoma	GDSC	SCHSELVPSP	DEG_COP1_1	0.2222
p.P421L	ACH-000108	Pancreatic Cancer	CCLE	SCHSELVPSP	DEG_COP1_1	0.2222
p.P421L	KP-3	pancreas	COSMIC	SCHSELVPSP	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N19	Integral membrane protein GPR137	DEG_COP1_1	408:417	SCHSELVPSP	COP1	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons