DegronMD - O60641(SNAP91)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A812V	TCGA-06-2561	GBM	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1389
p.T428S	TCGA-17-Z055	LUAD	TCGA	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.6005
p.P517R	TCGA-19-2631	GBM	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2222
p.S709C	TCGA-22-1000	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7541
p.S832P	TCGA-2W-A8YY	CESC	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.0833
p.S666W	TCGA-33-AASL	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.25
p.D438N	TCGA-3N-A9WD	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.0556
p.V430L	TCGA-43-7656	LUSC	TCGA	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2778
p.P517T	TCGA-58-8391	LUSC	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2222
p.P705H	TCGA-85-7950	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7694
p.A650S	TCGA-85-A4CL	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0833
p.P403A	TCGA-85-A4JB	LUSC	TCGA	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.25
p.P403A	TCGA-85-A4JB	LUSC	TCGA	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.1389
p.T704K	TCGA-86-8279	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.3056
p.A515T	TCGA-A5-A0G1	UCEC	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.T503A	TCGA-AA-A010	COAD	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.25
p.E569G	TCGA-AJ-A3BI	UCEC	TCGA	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.25
p.D562Y	TCGA-AX-A0J0	UCEC	TCGA	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation altering degron motif	0.6214
p.A435T	TCGA-AX-A1C4	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1389
p.A334T	TCGA-AX-A2HD	UCEC	TCGA	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1944
p.D668N	TCGA-B5-A11E	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1944
p.D323G	TCGA-B5-A1MR	UCEC	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.2778
p.A557D	TCGA-BS-A0UF	UCEC	TCGA	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.2222
p.P327L	TCGA-C5-A2LX	CESC	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.1667
p.T321N	TCGA-CA-6717	COAD	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.8166
p.S811I	TCGA-D1-A103	UCEC	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1111
p.T703K	TCGA-D7-8575	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.2778
p.V437L	TCGA-D8-A1JA	BRCA	TCGA	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.0833
p.V433G	TCGA-E6-A1LX	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1944
p.P517L	TCGA-EE-A17X	SKCM	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2222
p.G672E	TCGA-EE-A20C	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0833
p.G672E	DO37806	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0833
p.V833I	TCGA-EE-A2GC	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.0556
p.P506S	TCGA-EE-A2MI	SKCM	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation altering degron motif	0.6752
p.S401L	TCGA-EE-A3J5	SKCM	TCGA	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1944
p.S401L	TCGA-EE-A3J5	SKCM	TCGA	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.0833
p.P825S	TCGA-EE-A3JI	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2778
p.P825S	TCGA-FW-A3R5	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2778
p.D323N	TCGA-ER-A193	SKCM	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.2778
p.P820S	TCGA-FR-A729	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation altering degron motif	0.5641
p.P820S	TCGA-RP-A694	SKCM	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation altering degron motif	0.5641
p.G702E	TCGA-FS-A1ZS	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.25
p.P339S	TCGA-FU-A5XV	CESC	TCGA	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.6752
p.P523A	TCGA-GD-A2C5	BLCA	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.0556
p.S425F	TCGA-GN-A266	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.6871
p.A420V	TCGA-IB-7651	PAAD	TCGA	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1389
p.A420V	TCGA-IB-7651	PAAD	TCGA	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.1667
p.A420V	TCGA-IB-7651	PAAD	TCGA	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.A659S	TCGA-NJ-A55R	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	659:663	Mutation altering degron motif	0.7588
p.P809S	TCGA-R6-A6DN	ESCA	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.0556
p.F673V	TCGA-R6-A6L4	ESCA	TCGA	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0556
p.V824L	TCGA-RC-A6M3	LIHC	TCGA	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.3056
p.P705L	TCGA-S3-AA17	BRCA	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.P705L	DO51276	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.T704M	TCGA-YZ-A983	UVM	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.3056
p.A671S	TCGA-ZF-AA4V	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.T548I	TCGA-ZP-A9CZ	LIHC	TCGA	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.2778
p.P650S	DO219045	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0833
p.P521A	DO496	BLCA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1111
p.V435L	DO2819	BRCA	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1389
p.P715A	DO6231	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1667
p.G703R	DO49884	CESC	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.2778
p.P337S	DO48996	CESC	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.2778
p.P325L	DO49004	CESC	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation blocking phosphorylation signal	0.6667
p.T319N	DO8264	COAD	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.7055
p.L348P	DO224612	COCA	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1944
p.P515R	DO13809	GBM	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.A575V	DO16580	KIRC	ICGC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.0833
p.T425N	DO228924	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.7055
p.A719D	DO228976	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.0556
p.Q664K	DO228985	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.3056
p.T429N	DO229015	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.3056
p.P343T	DO229027	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation altering degron motif	0.7031
p.D353E	DO229032	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.0556
p.T331N	DO229038	LICA	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.0556
p.T331N	DO229038	LICA	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.T546I	DO52330	LIHC	ICGC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7078
p.V827I	DO219573	LIHC	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2222
p.A815S	DO23342	LINC	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.2222
p.P814H	DO45299	LIRI	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1944
p.P814H	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1944
p.P409L	DO229177	LMS	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.7582
p.P576L	DO51196	LUAD	ICGC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.0556
p.S651F	DO26846	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.S651F	DO220856	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.S651F	DO37477	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.S651F	DO47419	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.V428L	DO26424	LUSC	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.6765
p.P515T	DO45440	LUSC	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.P401A	DO45517	LUSC	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1944
p.P401A	DO45517	LUSC	ICGC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.0833
p.G816E	DO223718	LUSC	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.25
p.G816E	DO37483	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.25
p.G816E	COLO-792	skin	COSMIC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.25
p.D346N	DO52689	MALY	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.25
p.D346N	DO220906	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.25
p.M496I	DO220877	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.0556
p.P324S	DO220903	MELA	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation blocking phosphorylation signal	0.6944
p.P504S	DO222423	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.P504S	DO222721	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.P504S	DO37531	SKCM	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.P504S	DO37425	SKCM	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.P523L	DO222599	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.0556
p.P504L	DO222546	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.S522F	DO222696	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.0833
p.G811E	DO222775	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1111
p.G811E	DO47665	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1111
p.T331A	DO222908	MELA	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.0556
p.T331A	DO222908	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1111
p.P813H	DO46368	OV	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1667
p.A418V	DO46657	PAAD	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1944
p.A418V	DO46657	PAAD	ICGC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.2222
p.A418V	DO46657	PAAD	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1667
p.A418V	ACH-001991	Primary	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1944
p.A418V	ACH-001991	Primary	CCLE	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.2222
p.A418V	ACH-001991	Primary	CCLE	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1667
p.P707L	DO229453	SKCA	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.P652S	DO229502	SKCA	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1389
p.S423F	DO37432	SKCM	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.0556
p.S423F	DO37432	SKCM	ICGC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.0833
p.S423F	DO37432	SKCM	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.3056
p.M833I	DO50292	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.0556
p.F829L	DO47337	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1667
p.S399L	DO47331	SKCM	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1389
p.D321N	DO47368	SKCM	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.6932
p.P515L	DO37931	SKCM	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.P715S	DO37931	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1667
p.P715S	Mewo	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.1667
p.D436N	DO51235	SKCM	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1111
p.S651T	DO219482	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.T673K	DO47755	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0556
p.E567G	DO43450	UCEC	ICGC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.3056
p.V431G	DO41020	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.25
p.V708I	DO41752	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7076
p.D321G	DO41758	UCEC	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.7198
p.L437I	DO41758	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.0833
p.G811R	DO41911	UCEC	ICGC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1111
p.A332T	DO42608	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.A433T	DO42480	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1944
p.A513T	DO42472	UCEC	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation altering degron motif	0.7139
p.D560Y	DO41133	UCEC	ICGC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.3056
p.A555D	DO41488	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.A555D	DO41488	UCEC	ICGC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.1667
p.G829R	SIDM01278	Colorectal Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1667
p.A308T	SIDM02021	Esophageal Carcinoma	GDSC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.1667
p.E436K	SIDM01184	Bladder Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1111
p.E436K	ACH-000018	Bladder Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1111
p.E436K	ACH-000127	Bladder Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1111
p.E436K	T-24	urinary tract	COSMIC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1111
p.A660V	SIDM00845	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation altering degron motif	0.5825
p.V505A	SIDM00845	Burkitt's Lymphoma	GDSC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.3056
p.V505A	SIDM00461	Acute Myeloid Leukemia	GDSC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.3056
p.V505A	ACH-000786	Lymphoma	CCLE	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.3056
p.V505A	ACH-000992	Head and Neck Cancer	CCLE	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.3056
p.E569Q	SIDM00630	Breast Carcinoma	GDSC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.25
p.E569Q	ACH-000876	Breast Cancer	CCLE	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.25
p.E569Q	MDA-MB-415	breast	COSMIC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.25
p.A533D	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.A533D	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.A533D	SIDM00223	Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.A533D	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.A533D	SIDM01205	Acute Myeloid Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.A533D	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.A533D	SIDM00701	Non-Cancerous	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.0833
p.A520T	SIDM00761	Small Cell Lung Carcinoma	GDSC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1389
p.A520T	SIDM00928	Breast Carcinoma	GDSC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1389
p.S396F	SIDM00333	Endometrial Carcinoma	GDSC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.0556
p.S396F	ACH-000988	Endometrial/Uterine Cancer	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.0556
p.S396F	MFE-319	endometrium	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.0556
p.A319T	SIDM00333	Endometrial Carcinoma	GDSC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.6028
p.A319T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.6028
p.A319T	MFE-319	endometrium	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.6028
p.S649R	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0556
p.S649R	ACH-000781	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0556
p.S649R	NCI-H2023	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0556
p.P307S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.1389
p.P307S	H513	pleura	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.1389
p.A542T	SIDM01088	Endometrial Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7139
p.A542T	ACH-000965	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7139
p.A415S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.2778
p.A415S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.3056
p.A415S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.0833
p.A415S	ACH-000888	Lung Cancer	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.2778
p.A415S	ACH-000888	Lung Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.3056
p.A415S	ACH-000888	Lung Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.0833
p.A415S	NCI-H1793	lung	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.2778
p.A415S	NCI-H1793	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.3056
p.A415S	NCI-H1793	lung	COSMIC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.0833
p.A334S	SIDM00628	Breast Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1944
p.A334S	ACH-000849	Breast Cancer	CCLE	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1944
p.A334S	MDA-MB-468	breast	COSMIC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1944
p.S421P	SIDM01608	Endometrial Carcinoma	GDSC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1111
p.S421P	SIDM01608	Endometrial Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.1389
p.S421P	SIDM01608	Endometrial Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.25
p.S421P	ACH-000990	Endometrial/Uterine Cancer	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.1111
p.S421P	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.1389
p.S421P	ACH-000990	Endometrial/Uterine Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.25
p.S712P	SIDM01594	Breast Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.25
p.P831Q	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1111
p.P831Q	ACH-000921	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	819:823	Mutation rewiring degron network	0.1111
p.T431S	SIDM01619	Endometrial Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.25
p.T431S	ACH-000984	Endometrial/Uterine Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.25
p.T546A	ACH-000937	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7139
p.T547A	ACH-001061	Colon/Colorectal Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.3056
p.T412A	ACH-001699	Head and Neck Cancer	CCLE	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.6028
p.T412A	ACH-001699	Head and Neck Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation altering degron motif	0.7139
p.A317T	MFE-319	endometrium	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.7139
p.A413S	NCI-H1793	lung	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.7588
p.A413S	NCI-H1793	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation altering degron motif	0.7588
p.P654A	NCI-H835	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1944
p.D416E	ECC10	stomach	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.25
p.D416E	ECC10	stomach	COSMIC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.2778
p.D416E	ECC10	stomach	COSMIC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1111
p.A499T	SNU-1040	large intestine	COSMIC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation substituting flanking lysine	0.25
p.P537H	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1944
p.E434K	T-24	urinary tract	COSMIC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1667
p.E567Q	MDA-MB-415	breast	COSMIC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.3056
p.A318S	MDA-MB-468	breast	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.7588
p.P560L	KYSE-50	oesophagus	COSMIC	LDIFGD	LIG_APCC_ABBA_1	561:566	Mutation rewiring degron network	0.3056
p.P305S	H513	pleura	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation rewiring degron network	0.0833
p.A332S	MDA-MB-468	breast	COSMIC	PVSTS	DEG_SPOP_SBC_1	339:343	Mutation rewiring degron network	0.1389
p.A706E	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7701
p.D718E	ECC10	stomach	COSMIC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.0833
p.P438S	Mewo	skin	COSMIC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.0556
p.G539E	COLO-792	skin	COSMIC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.25
p.G415R	NCI-H446	lung	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation rewiring degron network	0.2778
p.G415R	NCI-H446	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation rewiring degron network	0.3056
p.G415R	NCI-H446	lung	COSMIC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.0833
p.A719S	GB-1	central nervous system	COSMIC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation rewiring degron network	0.0556
p.A429E	KM-H2	haematopoietic and lymphoid tissue	COSMIC	ASTTT	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNAP91

UniProt ID: O60641

Entrez ID: 9892

Protein name: Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNAP91 in