DegronMD - O60641(SNAP91)

FUNCTION: Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats (By similarity). {ECO:0000250}.

GO - Biological processes (BP): clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; protein transport [GO:0015031]; regulation of clathrin-dependent endocytosis [GO:2000369]; synaptic vesicle budding from presynaptic endocytic zone membrane [GO:0016185]; vesicle budding from membrane [GO:0006900]

GO - Molecular function (MF): 1-phosphatidylinositol binding [GO:0005545]; clathrin heavy chain binding [GO:0032050]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase binding [GO:0019901]; SNARE binding [GO:0000149]

GO - Cellular component (CC): clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; extrinsic component of presynaptic endocytic zone membrane [GO:0098894]; synaptic vesicle [GO:0008021]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T321N	TCGA-CA-6717	COAD	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.8166
p.A706E	KM-H2	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7701
p.P705H	TCGA-85-7950	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7694
p.A659S	TCGA-NJ-A55R	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	659:663	Mutation altering degron motif	0.7588
p.A413S	NCI-H1793	lung	COSMIC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.7588
p.A413S	NCI-H1793	lung	COSMIC	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation altering degron motif	0.7588
p.A318S	MDA-MB-468	breast	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.7588
p.P705L	TCGA-S3-AA17	BRCA	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.P705L	DO51276	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.P409L	DO229177	LMS	ICGC	PEPTPPTT	DEG_SCF_FBW7_1	406:413	Mutation altering degron motif	0.7582
p.P707L	DO229453	SKCA	ICGC	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7582
p.S709C	TCGA-22-1000	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	705:709	Mutation altering degron motif	0.7541
p.D321G	DO41758	UCEC	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.7198
p.A513T	DO42472	UCEC	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	506:513	Mutation altering degron motif	0.7139
p.A542T	SIDM01088	Endometrial Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7139
p.A542T	ACH-000965	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7139
p.T546A	ACH-000937	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7139
p.T412A	ACH-001699	Head and Neck Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	410:414	Mutation altering degron motif	0.7139
p.A317T	MFE-319	endometrium	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	314:321	Mutation altering degron motif	0.7139
p.T546I	DO52330	LIHC	ICGC	AATTT	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7078

Showing 1 to 20 of 230 entries

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Kaplan plot for SNAP91 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNAP91

UniProt ID: O60641

Entrez ID: 9892

Protein name: Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNAP91 in