DegronMD

Uniprot ID: O60641

Source protein: Clathrin coat assembly protein AP180

Source gene: SNAP91

Class: DEG_SCF_FBW7_1

Location: 506:513

E3 ligase: FBXW7

DEGRON score: 0.9683

ASA_SCORE: 91.5125

COIL: 0.9601

CONS_SCORE: 0.2317

DSS_SCORE: 0.5312

HELIX: 0.02

FCONS_SCORE: 0.9068

RIG_SCORE: 0.6866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P517R	TCGA-19-2631	GBM	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	0.2222
p.P517T	TCGA-58-8391	LUSC	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	0.2222
p.A515T	TCGA-A5-A0G1	UCEC	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.T503A	TCGA-AA-A010	COAD	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	0.25
p.P517L	TCGA-EE-A17X	SKCM	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	0.2222
p.P506S	TCGA-EE-A2MI	SKCM	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	0.6752
p.P523A	TCGA-GD-A2C5	BLCA	TCGA	PVVTPTAS	DEG_SCF_FBW7_1	0.0556
p.P521A	DO496	BLCA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.1111
p.P515R	DO13809	GBM	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.P515T	DO45440	LUSC	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.M496I	DO220877	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.0556
p.P504S	DO222423	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.P504S	DO222721	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.P504S	DO37531	SKCM	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.P504S	DO37425	SKCM	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.P523L	DO222599	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.0556
p.P504L	DO222546	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.S522F	DO222696	MELA	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.0833
p.P515L	DO37931	SKCM	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.2778
p.A513T	DO42472	UCEC	ICGC	PVVTPTAS	DEG_SCF_FBW7_1	0.7139
p.V505A	SIDM00845	Burkitt's Lymphoma	GDSC	PVVTPTAS	DEG_SCF_FBW7_1	0.3056
p.V505A	SIDM00461	Acute Myeloid Leukemia	GDSC	PVVTPTAS	DEG_SCF_FBW7_1	0.3056
p.V505A	ACH-000786	Lymphoma	CCLE	PVVTPTAS	DEG_SCF_FBW7_1	0.3056
p.V505A	ACH-000992	Head and Neck Cancer	CCLE	PVVTPTAS	DEG_SCF_FBW7_1	0.3056
p.A520T	SIDM00761	Small Cell Lung Carcinoma	GDSC	PVVTPTAS	DEG_SCF_FBW7_1	0.1389
p.A520T	SIDM00928	Breast Carcinoma	GDSC	PVVTPTAS	DEG_SCF_FBW7_1	0.1389
p.A499T	SNU-1040	large_intestine	COSMIC	PVVTPTAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SCF_FBW7_1	506:513	PVVTPTAS	FBXW7	0.9683	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVVTPTAS

Degron related mutations and impact score

Drug responses associated with SNAP91 mutations

All proteins holding degron of PVVTPTAS