DegronMD

Uniprot ID: O60641

Source protein: Clathrin coat assembly protein AP180

Source gene: SNAP91

Class: LIG_APCC_ABBA_1

Location: 561:566

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6024

ASA_SCORE: 67

COIL: 0.7177

CONS_SCORE: 0.2741

DSS_SCORE: 0.4422

HELIX: 0.1717

FCONS_SCORE: 1.1076

RIG_SCORE: 0.8166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E569G	TCGA-AJ-A3BI	UCEC	TCGA	LDIFGD	LIG_APCC_ABBA_1	0.25
p.D562Y	TCGA-AX-A0J0	UCEC	TCGA	LDIFGD	LIG_APCC_ABBA_1	0.6214
p.A557D	TCGA-BS-A0UF	UCEC	TCGA	LDIFGD	LIG_APCC_ABBA_1	0.2222
p.A575V	DO16580	KIRC	ICGC	LDIFGD	LIG_APCC_ABBA_1	0.0833
p.P576L	DO51196	LUAD	ICGC	LDIFGD	LIG_APCC_ABBA_1	0.0556
p.E567G	DO43450	UCEC	ICGC	LDIFGD	LIG_APCC_ABBA_1	0.3056
p.D560Y	DO41133	UCEC	ICGC	LDIFGD	LIG_APCC_ABBA_1	0.3056
p.A555D	DO41488	UCEC	ICGC	LDIFGD	LIG_APCC_ABBA_1	0.1667
p.E569Q	SIDM00630	Breast Carcinoma	GDSC	LDIFGD	LIG_APCC_ABBA_1	0.25
p.E569Q	ACH-000876	Breast Cancer	CCLE	LDIFGD	LIG_APCC_ABBA_1	0.25
p.E569Q	MDA-MB-415	breast	COSMIC	LDIFGD	LIG_APCC_ABBA_1	0.25
p.E567Q	MDA-MB-415	breast	COSMIC	LDIFGD	LIG_APCC_ABBA_1	0.3056
p.P560L	KYSE-50	oesophagus	COSMIC	LDIFGD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	LIG_APCC_ABBA_1	561:566	LDIFGD	APC,CDC20,FZR1	0.6024	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons