DegronMD

Uniprot ID: O60641

Source protein: Clathrin coat assembly protein AP180

Source gene: SNAP91

Class: DEG_SPOP_SBC_1

Location: 542:546

E3 ligase: SPOP

DEGRON score: 0.611

ASA_SCORE: 89.36

COIL: 0.8224

CONS_SCORE: 0.1773

DSS_SCORE: 0.4007

HELIX: 0.156

FCONS_SCORE: 0.9437

RIG_SCORE: 0.7481

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T548I	TCGA-ZP-A9CZ	LIHC	TCGA	AATTT	DEG_SPOP_SBC_1	0.2778
p.T546I	DO52330	LIHC	ICGC	AATTT	DEG_SPOP_SBC_1	0.7078
p.A555D	DO41488	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A533D	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A533D	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A533D	SIDM00223	Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A533D	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A533D	SIDM01205	Acute Myeloid Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A533D	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A533D	SIDM00701	Non-Cancerous	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A542T	SIDM01088	Endometrial Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.7139
p.A542T	ACH-000965	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.7139
p.T546A	ACH-000937	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	0.7139
p.T547A	ACH-001061	Colon/Colorectal Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.3056
p.P537H	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.1944
p.G539E	COLO-792	skin	COSMIC	AATTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons