DegronMD

Uniprot ID: Q9UKB5

Source protein: Adherens junction-associated protein 1

Source gene: AJAP1

Class: DEG_SPOP_SBC_1

Location: 217:221

E3 ligase: SPOP

DEGRON score: 0.9943

ASA_SCORE: 88.76

COIL: 0.7798

CONS_SCORE: 0.7729

DSS_SCORE: 0.5177

HELIX: 0.0168

FCONS_SCORE: 1.2495

RIG_SCORE: 0.7873

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M229T	TCGA-58-8388	LUSC	TCGA	AATTT	DEG_SPOP_SBC_1	0.1111
p.M229T	DO45552	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1111
p.R212W	TCGA-A5-A0VP	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.1944
p.R212W	DO42600	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1944
p.T225M	TCGA-AX-A2IN	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.2222
p.T225M	TCGA-KK-A59V	PRAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.2222
p.T225M	DO51346	PRAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.2222
p.T225M	DO42328	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.2222
p.I208V	TCGA-DI-A1BU	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.0833
p.I208V	DO42023	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.0833
p.A218T	TCGA-EO-A3L0	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.6028
p.A218T	DO219775	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.6028
p.A218T	DO229542	UTCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.6028
p.A218T	SIDM00815	Ovarian Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.6028
p.T222I	TCGA-FR-A726	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	0.3056
p.T222I	DO48665	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.V216L	TCGA-KO-8417	KICH	TCGA	AATTT	DEG_SPOP_SBC_1	0.3056
p.V216L	DO220608	KICH	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.T230M	TCGA-MP-A4SW	LUAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.5278
p.T230M	DO222427	BTCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.5278
p.T230M	DO45313	LUAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.5278
p.T230M	DO218280	ORCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.5278
p.T230A	TCGA-WW-A8ZI	PRAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.5278
p.T230A	DO49865	PRAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.5278
p.T219A	DO227979	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.7139
p.T219A	SIDM00032	Bladder Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.7139
p.V216M	DO232224	PBCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.R212L	SIDM01196	Hepatocellular Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.1944
p.R212L	ACH-000422	Liver Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.1944
p.R212L	SNU-475	liver	COSMIC	AATTT	DEG_SPOP_SBC_1	0.1944
p.A217G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.754
p.T223I	SIDM00214	Colorectal Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2778
p.T223I	ACH-000955	Colon/Colorectal Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATTT

Degron related mutations and impact score

Drug responses associated with AJAP1 mutations

All proteins holding degron of AATTT