DegronMD

Uniprot ID: O60907

Source protein: F-box-like/WD repeat-containing protein TBL1X

Source gene: TBL1X

Class: DEG_SPOP_SBC_1

Location: 174:178

E3 ligase: SPOP

DEGRON score: 0.6842

ASA_SCORE: 79.2

COIL: 0.652

CONS_SCORE: 0.2565

DSS_SCORE: 0.4859

HELIX: 0.274

FCONS_SCORE: 0.8896

RIG_SCORE: 0.6828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V182I	TCGA-12-0692	GBM	TCGA	AATTT	DEG_SPOP_SBC_1	0.2222
p.A170S	TCGA-55-A492	LUAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.2222
p.A164V	TCGA-5M-AAT6	COAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.0556
p.S188L	TCGA-EO-A22U	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.0556
p.T175A	DO6466	CLLE	ICGC	AATTT	DEG_SPOP_SBC_1	0.7139
p.R178Q	DO10694	COAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.7329
p.G179V	DO229019	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.G179V	DO229028	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	0.3056
p.I186M	DO231602	LINC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1111
p.R178W	DO35442	PACA	ICGC	AATTT	DEG_SPOP_SBC_1	0.8634
p.L177I	DO37782	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	0.7174
p.H180R	DO42472	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.2778
p.A165V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.S183P	ACH-000993	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons