DegronMD - Q9UKB5(AJAP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A145D	TCGA-2Y-A9GU	LIHC	TCGA	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.A145D	DO219507	LIHC	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.M229T	TCGA-58-8388	LUSC	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1111
p.M229T	DO45552	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1111
p.A363T	TCGA-A5-A0G2	UCEC	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.2778
p.A363T	DO41235	UCEC	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.2778
p.R212W	TCGA-A5-A0VP	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1944
p.R212W	DO42600	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1944
p.S364Y	TCGA-AA-A010	COAD	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.3056
p.D370N	TCGA-AJ-A3EL	UCEC	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6932
p.D370N	DO229456	SKCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6932
p.D370N	DO41542	UCEC	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6932
p.A140T	TCGA-AP-A1DV	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A140T	TCGA-DM-A0XD	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A140T	DO10228	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A140T	DO43186	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.T225M	TCGA-AX-A2IN	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2222
p.T225M	TCGA-KK-A59V	PRAD	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2222
p.T225M	DO51346	PRAD	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2222
p.T225M	DO42328	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2222
p.Y380C	TCGA-BG-A222	UCEC	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.0556
p.Y380C	DO42977	UCEC	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.0556
p.T376M	TCGA-BS-A0UV	UCEC	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1667
p.T376M	TCGA-FD-A62P	BLCA	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1667
p.T376M	DO44054	BLCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1667
p.T376M	DO42793	UCEC	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1667
p.T376M	SIDM01559	Melanoma	GDSC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1667
p.S375L	TCGA-C8-A12L	BRCA	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1944
p.S375L	DO2055	BRCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1944
p.S375L	DO234431	ESAD	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1944
p.V367M	TCGA-CD-A4MG	STAD	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6097
p.V367M	TCGA-EJ-A65M	PRAD	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6097
p.V367M	DO233762	GACA	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6097
p.V367M	DO49758	PRAD	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6097
p.V367M	DO48009	STAD	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6097
p.V367M	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6097
p.V367M	ACH-000628	Lung Cancer	CCLE	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6097
p.V367M	NCI-H596	lung	COSMIC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation altering degron motif	0.6097
p.A363V	TCGA-CN-4729	HNSC	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.2778
p.A363V	DO16029	HNSC	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.2778
p.I208V	TCGA-DI-A1BU	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.0833
p.I208V	DO42023	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.0833
p.A218T	TCGA-EO-A3L0	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6028
p.A218T	DO219775	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6028
p.A218T	DO229542	UTCA	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6028
p.A218T	SIDM00815	Ovarian Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.6028
p.C360Y	TCGA-ER-A2NH	SKCM	TCGA	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1944
p.C360Y	DO47683	SKCM	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1944
p.T222I	TCGA-FR-A726	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.T222I	DO48665	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.P121S	TCGA-FW-A3R5	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.P121S	DO37406	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.A140V	TCGA-IB-7890	PAAD	TCGA	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A140V	DO233202	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A140V	DO233749	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A140V	DO23358	LINC	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A140V	DO46637	PAAD	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A140V	DO35218	PACA	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.V216L	TCGA-KO-8417	KICH	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.V216L	DO220608	KICH	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.T230M	TCGA-MP-A4SW	LUAD	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation blocking phosphorylation signal	0.5278
p.T230M	DO222427	BTCA	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation blocking phosphorylation signal	0.5278
p.T230M	DO45313	LUAD	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation blocking phosphorylation signal	0.5278
p.T230M	DO218280	ORCA	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation blocking phosphorylation signal	0.5278
p.T230A	TCGA-WW-A8ZI	PRAD	TCGA	AATTT	DEG_SPOP_SBC_1	217:221	Mutation blocking phosphorylation signal	0.5278
p.T230A	DO49865	PRAD	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation blocking phosphorylation signal	0.5278
p.S135P	DO222427	BTCA	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.6752
p.S137P	DO8858	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.T219A	DO227979	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.7139
p.T219A	SIDM00032	Bladder Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.7139
p.E371K	DO234309	ESAD	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.3056
p.K125E	DO233089	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation substituting flanking lysine	0.2778
p.P128H	DO233272	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.25
p.C360F	DO229019	LICA	ICGC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1944
p.S129F	DO220903	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation blocking phosphorylation signal	0.7222
p.V216M	DO232224	PBCA	ICGC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.3056
p.A131T	SIDM02035	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7139
p.A142V	SIDM01090	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1389
p.A142V	ACH-000943	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1389
p.A142V	RKO	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1389
p.R212L	SIDM01196	Hepatocellular Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1944
p.R212L	ACH-000422	Liver Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1944
p.R212L	SNU-475	liver	COSMIC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.1944
p.G143S	SIDM00282	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.G143S	ACH-000740	Head and Neck Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.G143S	ACH-000998	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.G143S	CW-2	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.A217G	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation altering degron motif	0.754
p.T377M	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1389
p.T377M	SIDM00996	Thyroid Gland Carcinoma	GDSC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1389
p.T377M	KNS-62	lung	COSMIC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1389
p.T377M	8505C	thyroid	COSMIC	VPVYTD	LIG_APCC_ABBA_1	365:370	Mutation rewiring degron network	0.1389
p.T223I	SIDM00214	Colorectal Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2778
p.T223I	ACH-000955	Colon/Colorectal Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	217:221	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AJAP1

UniProt ID: Q9UKB5

Entrez ID: 55966

Protein name: Adherens junction-associated protein 1 (Membrane protein shrew-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AJAP1 in