DegronMD

Uniprot ID: Q9UKB5

Source protein: Adherens junction-associated protein 1

Source gene: AJAP1

Class: LIG_APCC_ABBA_1

Location: 365:370

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8738

ASA_SCORE: 66.5333

COIL: 0.7903

CONS_SCORE: 0.8931

DSS_SCORE: 0.3155

HELIX: 0.0572

FCONS_SCORE: 1.1192

RIG_SCORE: 0.7909

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A363T	TCGA-A5-A0G2	UCEC	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.2778
p.A363T	DO41235	UCEC	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.2778
p.S364Y	TCGA-AA-A010	COAD	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.3056
p.D370N	TCGA-AJ-A3EL	UCEC	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.6932
p.D370N	DO229456	SKCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.6932
p.D370N	DO41542	UCEC	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.6932
p.Y380C	TCGA-BG-A222	UCEC	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.0556
p.Y380C	DO42977	UCEC	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.0556
p.T376M	TCGA-BS-A0UV	UCEC	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.1667
p.T376M	TCGA-FD-A62P	BLCA	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.1667
p.T376M	DO44054	BLCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1667
p.T376M	DO42793	UCEC	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1667
p.T376M	SIDM01559	Melanoma	GDSC	VPVYTD	LIG_APCC_ABBA_1	0.1667
p.S375L	TCGA-C8-A12L	BRCA	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.1944
p.S375L	DO2055	BRCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1944
p.S375L	DO234431	ESAD	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1944
p.V367M	TCGA-CD-A4MG	STAD	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.6097
p.V367M	TCGA-EJ-A65M	PRAD	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.6097
p.V367M	DO233762	GACA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.6097
p.V367M	DO49758	PRAD	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.6097
p.V367M	DO48009	STAD	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.6097
p.V367M	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	VPVYTD	LIG_APCC_ABBA_1	0.6097
p.V367M	ACH-000628	Lung Cancer	CCLE	VPVYTD	LIG_APCC_ABBA_1	0.6097
p.V367M	NCI-H596	lung	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.6097
p.A363V	TCGA-CN-4729	HNSC	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.2778
p.A363V	DO16029	HNSC	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.2778
p.C360Y	TCGA-ER-A2NH	SKCM	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.1944
p.C360Y	DO47683	SKCM	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1944
p.E371K	DO234309	ESAD	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.3056
p.C360F	DO229019	LICA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1944
p.T377M	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	VPVYTD	LIG_APCC_ABBA_1	0.1389
p.T377M	SIDM00996	Thyroid Gland Carcinoma	GDSC	VPVYTD	LIG_APCC_ABBA_1	0.1389
p.T377M	KNS-62	lung	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.1389
p.T377M	8505C	thyroid	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPVYTD

Degron related mutations and impact score

Drug responses associated with AJAP1 mutations

All proteins holding degron of VPVYTD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKB5	Adherens junction-associated protein 1	LIG_APCC_ABBA_1	365:370	VPVYTD	APC,CDC20,FZR1	0.8738	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	LIG_APCC_ABBA_1	365:370	VPVYTD	APC,CDC20,FZR1	0.994	More...