DegronMD

Uniprot ID: Q96EK7

Source protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma

Source gene: FAM120B

Class: LIG_APCC_ABBA_1

Location: 365:370

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.994

ASA_SCORE: 98.4333

COIL: 0.947

CONS_SCORE: 0.4641

DSS_SCORE: 0.6532

HELIX: 0.0148

FCONS_SCORE: 1.0088

RIG_SCORE: 0.6928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P378T	TCGA-38-4631	LUAD	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.1111
p.P366L	TCGA-FW-A3R5	SKCM	TCGA	VPVYTD	LIG_APCC_ABBA_1	0.6471
p.P366L	DO37719	SKCM	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.6471
p.S373A	DO225381	BRCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.25
p.M367T	DO222812	BTCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.7423
p.M367T	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.7423
p.S361P	DO222812	BTCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.2222
p.A359T	DO12346	GBM	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1667
p.V379M	DO224546	LUSC	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.0833
p.R375Q	DO218859	SKCA	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1944
p.P378L	DO37406	SKCM	ICGC	VPVYTD	LIG_APCC_ABBA_1	0.1111
p.M378T	SIDM00087	Plasma Cell Myeloma	GDSC	VPVYTD	LIG_APCC_ABBA_1	0.1111
p.M378T	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.1111
p.T380S	SIDM00087	Plasma Cell Myeloma	GDSC	VPVYTD	LIG_APCC_ABBA_1	0.0556
p.M355T	ACH-000817	Myeloma	CCLE	VPVYTD	LIG_APCC_ABBA_1	0.0556
p.M355T	ACH-001163	Kidney Cancer	CCLE	VPVYTD	LIG_APCC_ABBA_1	0.0556
p.M355T	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.0556
p.Q375R	ACH-001057	Lymphoma	CCLE	VPVYTD	LIG_APCC_ABBA_1	0.1944
p.P373S	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.25
p.G370D	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.7198
p.G358D	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VPVYTD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKB5	Adherens junction-associated protein 1	LIG_APCC_ABBA_1	365:370	VPVYTD	APC,CDC20,FZR1	0.8738	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	LIG_APCC_ABBA_1	365:370	VPVYTD	APC,CDC20,FZR1	0.994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons