DegronMD

Uniprot ID: Q8IYB3

Source protein: Serine/arginine repetitive matrix protein 1

Source gene: SRRM1

Class: DEG_SPOP_SBC_1

Location: 852:856

E3 ligase: SPOP

DEGRON score: 0.9784

ASA_SCORE: 93.7

COIL: 0.9438

CONS_SCORE: 0.3175

DSS_SCORE: 0.5173

HELIX: 0.0396

FCONS_SCORE: 0.9344

RIG_SCORE: 0.7602

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T856A	TCGA-CM-5341	COAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.825
p.T855I	SIDM00410	Other Blood Cancers	GDSC	AATTT	DEG_SPOP_SBC_1	0.8189
p.T855I	ACH-002317	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	0.8189
p.T855I	YT	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.8189
p.A858T	TCGA-BG-A0MC	UCEC	TCGA	AATTT	DEG_SPOP_SBC_1	0.2778
p.A860S	DO229037	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	0.2222
p.E861Q	TCGA-MV-A51V	BLCA	TCGA	AATTT	DEG_SPOP_SBC_1	0.1944
p.E861Q	DO474	BLCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.1944
p.V863A	TCGA-DD-AACD	LIHC	TCGA	AATTT	DEG_SPOP_SBC_1	0.1389
p.A845V	DO46657	PAAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.1389
p.T864I	YT	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.1111
p.T865A	DO10060	COAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.0833

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...

Showing 1 to 18 of 18 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons