DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SPOP_SBC_1

Location: 69:73

E3 ligase: SPOP

DEGRON score: 0.9948

ASA_SCORE: 80.42

COIL: 0.8372

CONS_SCORE: 0.2677

DSS_SCORE: 0.5363

HELIX: 0.1236

FCONS_SCORE: 0.9062

RIG_SCORE: 0.6898

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R81P	TCGA-43-5668	LUSC	TCGA	AATTT	DEG_SPOP_SBC_1	0.1111
p.R81P	DO26608	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1111
p.D62G	TCGA-BR-8680	STAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.1389
p.D62G	DO47769	STAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.1389
p.H59N	TCGA-D3-A2JG	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	0.0556
p.H59N	DO47613	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.T74A	TCGA-GV-A6ZA	BLCA	TCGA	AATTT	DEG_SPOP_SBC_1	0.75
p.T74A	DO49776	BLCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.75
p.R59H	DO5521	BRCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.A70V	DO6568	CLLE	ICGC	AATTT	DEG_SPOP_SBC_1	0.5825
p.G67E	DO11854	GBM	ICGC	AATTT	DEG_SPOP_SBC_1	0.2778
p.R59C	DO20766	KIRP	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.R59C	DO219776	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.R59C	DO43186	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.R59C	DO41331	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.R59C	CHSA0011	bone	COSMIC	AATTT	DEG_SPOP_SBC_1	0.0556
p.A83S	DO228986	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.V78L	DO229028	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	0.1944
p.A67S	DO229035	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	0.2778
p.R59L	DO23907	LUAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.R79Q	DO228326	MALY	ICGC	AATTT	DEG_SPOP_SBC_1	0.1667
p.R66S	DO228338	MALY	ICGC	AATTT	DEG_SPOP_SBC_1	0.25
p.R66S	SIDM00948	Burkitt's Lymphoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.25
p.R66S	ACH-002232	Lymphoma	CCLE	AATTT	DEG_SPOP_SBC_1	0.25
p.R66S	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.25
p.T60I	DO229268	THCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.5278
p.F72S	DO229272	THCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.7982
p.R82G	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.0833
p.R82G	ACH-000603	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.0833
p.R82G	BEN	lung	COSMIC	AATTT	DEG_SPOP_SBC_1	0.0833
p.R81H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	0.1111
p.R81H	ACH-002222	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	0.1111
p.R81H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.1111
p.L83H	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.0556
p.L83H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.0556
p.H70R	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.8244
p.H70R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.8244
p.S82N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.0833
p.S82N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AATTT

Degron related mutations and impact score

Drug responses associated with WNK1 mutations

All proteins holding degron of AATTT