DegronMD

Uniprot ID: O60641

Source protein: Clathrin coat assembly protein AP180

Source gene: SNAP91

Class: DEG_SPOP_SBC_1

Location: 424:428

E3 ligase: SPOP

DEGRON score: 0.9865

ASA_SCORE: 82.18

COIL: 0.933

CONS_SCORE: 0.2364

DSS_SCORE: 0.4073

HELIX: 0.0422

FCONS_SCORE: 0.9922

RIG_SCORE: 0.718

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T428S	TCGA-17-Z055	LUAD	TCGA	ASTTT	DEG_SPOP_SBC_1	0.6005
p.D438N	TCGA-3N-A9WD	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	0.0556
p.V430L	TCGA-43-7656	LUSC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.2778
p.A435T	TCGA-AX-A1C4	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.1389
p.V437L	TCGA-D8-A1JA	BRCA	TCGA	ASTTT	DEG_SPOP_SBC_1	0.0833
p.V433G	TCGA-E6-A1LX	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.1944
p.S425F	TCGA-GN-A266	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	0.6871
p.A420V	TCGA-IB-7651	PAAD	TCGA	ASTTT	DEG_SPOP_SBC_1	0.2222
p.V435L	DO2819	BRCA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1389
p.T425N	DO228924	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.7055
p.T429N	DO229015	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.3056
p.V428L	DO26424	LUSC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.6765
p.A418V	DO46657	PAAD	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.A418V	ACH-001991	Primary	CCLE	ASTTT	DEG_SPOP_SBC_1	0.1667
p.S423F	DO37432	SKCM	ICGC	ASTTT	DEG_SPOP_SBC_1	0.3056
p.D436N	DO51235	SKCM	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1111
p.V431G	DO41020	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.25
p.L437I	DO41758	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.A433T	DO42480	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1944
p.E436K	SIDM01184	Bladder Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.1111
p.E436K	ACH-000018	Bladder Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.1111
p.E436K	ACH-000127	Bladder Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.1111
p.E436K	T-24	urinary_tract	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.1111
p.A415S	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.A415S	ACH-000888	Lung Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.0833
p.A415S	NCI-H1793	lung	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.S421P	SIDM01608	Endometrial Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.25
p.S421P	ACH-000990	Endometrial/Uterine Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.25
p.T431S	SIDM01619	Endometrial Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.25
p.T431S	ACH-000984	Endometrial/Uterine Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.25
p.D416E	ECC10	stomach	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.1111
p.E434K	T-24	urinary_tract	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.P438S	Mewo	skin	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.0556
p.G415R	NCI-H446	lung	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.A429E	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	424:428	ASTTT	SPOP	0.9865	More...
P81274	G-protein-signaling modulator 2	DEG_SPOP_SBC_1	519:523	ASTTT	SPOP	0.9496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2347:2351	ASTTT	SPOP	0.9971	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	1056:1060	ASTTT	SPOP	0.9961	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	134:138	ASTTT	SPOP	0.999	More...
Q9UPN6	SR-related and CTD-associated factor 8	DEG_SPOP_SBC_1	148:152	ASTTT	SPOP	0.9821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTTT

Degron related mutations and impact score

Drug responses associated with SNAP91 mutations

All proteins holding degron of ASTTT