DegronMD

Uniprot ID: Q96H15

Source protein: T-cell immunoglobulin and mucin domain-containing protein 4

Source gene: TIMD4

Class: DEG_SPOP_SBC_1

Location: 134:138

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 76.8

COIL: 0.9164

CONS_SCORE: 0.3743

DSS_SCORE: 0.528

HELIX: 0.013

FCONS_SCORE: 0.7868

RIG_SCORE: 0.7207

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R128C	TCGA-06-0190	GBM	TCGA	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	TCGA-CG-4300	STAD	TCGA	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	DO10975	GBM	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	DO38767	STAD	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	SIDM00945	Colorectal Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	SIDM00217	Colorectal Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	ACH-000895	Colon/Colorectal Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	ACH-000999	Colon/Colorectal Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	SNU-1040	large_intestine	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128C	CL-34	large_intestine	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R140K	TCGA-21-1079	LUSC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.2778
p.R140K	TCGA-D3-A1Q6	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	0.2778
p.R140K	DO26846	LUSC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.2778
p.R140K	DO37450	SKCM	ICGC	ASTTT	DEG_SPOP_SBC_1	0.2778
p.Q132L	TCGA-77-8136	LUSC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.2778
p.Q132L	DO26593	LUSC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.2778
p.T137N	TCGA-86-7955	LUAD	TCGA	ASTTT	DEG_SPOP_SBC_1	0.7055
p.T137N	DO229045	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.7055
p.T137N	DO23612	LUAD	ICGC	ASTTT	DEG_SPOP_SBC_1	0.7055
p.R147H	TCGA-A5-A0GA	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147H	TCGA-D1-A15X	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147H	DO43274	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147H	DO43763	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147C	TCGA-BH-A18F	BRCA	TCGA	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147C	DO4074	BRCA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147C	DO233020	GACA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147C	DO227579	ORCA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147C	SIDM00150	Colorectal Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R128H	TCGA-CM-4750	COAD	TCGA	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128H	TCGA-L5-A8NE	ESCA	TCGA	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128H	DO9298	COAD	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R128H	DO232761	PBCA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1667
p.R133G	TCGA-CV-A463	HNSC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.3056
p.R133G	DO52066	HNSC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.3056
p.A142T	TCGA-DU-7302	LGG	TCGA	ASTTT	DEG_SPOP_SBC_1	0.2222
p.A142T	DO22728	LGG	ICGC	ASTTT	DEG_SPOP_SBC_1	0.2222
p.V127M	DO233776	GACA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1389
p.R147S	DO228986	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.R147S	DO50737	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.A134D	DO228986	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.7793
p.T141K	DO229008	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.25
p.T145I	DO222595	MELA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1389
p.Q132K	DO229232	THCA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.2778
p.T138M	SIDM00220	Ovarian Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.7423
p.T138M	ACH-000962	Ovarian Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.7423
p.T138M	ACH-001145	Ovarian Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.7423
p.T138M	OC-314	ovary	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	424:428	ASTTT	SPOP	0.9865	More...
P81274	G-protein-signaling modulator 2	DEG_SPOP_SBC_1	519:523	ASTTT	SPOP	0.9496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2347:2351	ASTTT	SPOP	0.9971	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	1056:1060	ASTTT	SPOP	0.9961	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	134:138	ASTTT	SPOP	0.999	More...
Q9UPN6	SR-related and CTD-associated factor 8	DEG_SPOP_SBC_1	148:152	ASTTT	SPOP	0.9821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTTT

Degron related mutations and impact score

Drug responses associated with TIMD4 mutations

All proteins holding degron of ASTTT