DegronMD - Q9UPN6(SCAF8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S835F	TCGA-CV-7411	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.6871
p.P158Q	TCGA-EE-A181	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.N156T	TCGA-FS-A1ZK	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.A153P	TCGA-G9-A9S7	PRAD	TCGA	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.R153T	DO234283	ESAD	ICGC	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.I840T	DO23186	LINC	ICGC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.R140Q	DO40884	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1111
p.H141Y	DO40843	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1389
p.R153I	DO41572	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.3056
p.G832V	SIDM00193	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.G832V	SNU-81	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778
p.A837V	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.6936
p.A837V	HOP-62	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.6936
p.A837T	SIDM00807	Bladder Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.7139
p.A837T	5637	urinary tract	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.7139
p.V161L	SIDM01609	Endometrial Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.P161S	ACH-000975	Lung Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.0833
p.A825V	HOP-62	lung	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.0833
p.P837L	OV-7	ovary	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation altering degron motif	0.7582
p.N157Y	HT55	large intestine	COSMIC	ASTTT	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1944
p.A825T	5637	urinary tract	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.0833
p.I840V	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	834:838	Mutation rewiring degron network	0.2778

Kaplan plot for SCAF8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAF8

UniProt ID: Q9UPN6

Entrez ID: 22828

Protein name: SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCAF8 in