DegronMD

Uniprot ID: Q9UPN6

Source protein: SR-related and CTD-associated factor 8

Source gene: SCAF8

Class: DEG_SPOP_SBC_1

Location: 148:152

E3 ligase: SPOP

DEGRON score: 0.9821

ASA_SCORE: 78.82

COIL: 0.8068

CONS_SCORE: 0.2756

DSS_SCORE: 0.4498

HELIX: 0.168

FCONS_SCORE: 0.7797

RIG_SCORE: 0.7356

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P158Q	TCGA-EE-A181	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	0.1667
p.N156T	TCGA-FS-A1ZK	SKCM	TCGA	ASTTT	DEG_SPOP_SBC_1	0.2222
p.A153P	TCGA-G9-A9S7	PRAD	TCGA	ASTTT	DEG_SPOP_SBC_1	0.3056
p.R153T	DO234283	ESAD	ICGC	ASTTT	DEG_SPOP_SBC_1	0.3056
p.R140Q	DO40884	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1111
p.H141Y	DO40843	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1389
p.R153I	DO41572	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.3056
p.V161L	SIDM01609	Endometrial Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.0833
p.P161S	ACH-000975	Lung Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.0833
p.N157Y	HT55	large_intestine	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	424:428	ASTTT	SPOP	0.9865	More...
P81274	G-protein-signaling modulator 2	DEG_SPOP_SBC_1	519:523	ASTTT	SPOP	0.9496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2347:2351	ASTTT	SPOP	0.9971	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	1056:1060	ASTTT	SPOP	0.9961	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	134:138	ASTTT	SPOP	0.999	More...
Q9UPN6	SR-related and CTD-associated factor 8	DEG_SPOP_SBC_1	148:152	ASTTT	SPOP	0.9821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons