DegronMD

Uniprot ID: P81274

Source protein: G-protein-signaling modulator 2

Source gene: GPSM2

Class: DEG_SPOP_SBC_1

Location: 519:523

E3 ligase: SPOP

DEGRON score: 0.9496

ASA_SCORE: 82.1

COIL: 0.8368

CONS_SCORE: 0.46

DSS_SCORE: 0.502

HELIX: 0.1248

FCONS_SCORE: 0.9955

RIG_SCORE: 0.6545

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C509R	TCGA-2W-A8YY	CESC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.0556
p.C509R	DO223732	CESC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.0556
p.A519T	TCGA-AX-A1CE	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.7139
p.A519T	DO42280	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.7139
p.K514N	TCGA-CA-6718	COAD	TCGA	ASTTT	DEG_SPOP_SBC_1	0.3056
p.K514N	DO7801	COAD	ICGC	ASTTT	DEG_SPOP_SBC_1	0.3056
p.S524T	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00770	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00672	Hepatocellular Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00376	B-Lymphoblastic Leukemia	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01015	Chronic Myelogenous Leukemia	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01119	Other Solid Cancers	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00773	Non-Cancerous	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00957	Colorectal Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00935	Other Solid Cancers	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01203	Other Solid Cancers	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00648	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00086	Kidney Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00915	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00969	Ovarian Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01179	Other Sarcomas	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00107	Melanoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00392	Melanoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00678	Bladder Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01174	Cervical Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00656	Burkitt's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01002	Breast Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00262	Ewing's Sarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00413	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01057	Acute Myeloid Leukemia	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00741	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00583	Pancreatic Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01087	Melanoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01178	Other Solid Cancers	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00264	Ewing's Sarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00690	Head and Neck Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00417	Plasma Cell Myeloma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01112	Osteosarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01161	Other Sarcomas	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01134	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00529	Breast Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00095	Glioblastoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00650	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00869	Non-Cancerous	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00694	Other Solid Cancers	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00203	Ewing's Sarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01110	Hepatocellular Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00686	Endometrial Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00806	Osteosarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00136	Colorectal Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01073	Other Blood Cancers	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01132	Other Solid Cancers	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00666	Glioma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00035	Thyroid Gland Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00849	Kidney Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00858	Osteosarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00003	Melanoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00898	Breast Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00032	Bladder Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01220	Glioma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01121	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00793	Burkitt's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00621	Ewing's Sarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01193	Glioma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00999	Bladder Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00863	Burkitt's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01681	Non-Cancerous	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00816	Kidney Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00196	Ewing's Sarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00736	Non-Cancerous	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00213	Thyroid Gland Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00485	Oral Cavity Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00679	Cervical Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00124	Kidney Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01246	Ewing's Sarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00774	Breast Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00100	Mesothelioma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00720	Mesothelioma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00673	Breast Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00808	Burkitt's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00760	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00976	Melanoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00224	Mesothelioma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00628	Breast Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01545	Non-Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01318	Hepatocellular Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00641	Burkitt's Lymphoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01629	Melanoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01480	Ovarian Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01398	Melanoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01664	Prostate Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00634	Ewing's Sarcoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM00228	Thyroid Gland Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75
p.S524T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	424:428	ASTTT	SPOP	0.9865	More...
P81274	G-protein-signaling modulator 2	DEG_SPOP_SBC_1	519:523	ASTTT	SPOP	0.9496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2347:2351	ASTTT	SPOP	0.9971	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	1056:1060	ASTTT	SPOP	0.9961	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	134:138	ASTTT	SPOP	0.999	More...
Q9UPN6	SR-related and CTD-associated factor 8	DEG_SPOP_SBC_1	148:152	ASTTT	SPOP	0.9821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTTT

Degron related mutations and impact score

Drug responses associated with GPSM2 mutations

All proteins holding degron of ASTTT