DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
ASTTT
Uniprot ID:
Q12830
Source protein:
Nucleosome-remodeling factor subunit BPTF
Source gene:
BPTF
Class:
DEG_SPOP_SBC_1
Location:
2347:2351
E3 ligase:
SPOP
DEGRON score:
0.9971
ASA_SCORE:
91.2
COIL:
0.954
CONS_SCORE:
0.2673
DSS_SCORE:
0.4834
HELIX:
0.0144
FCONS_SCORE:
0.7129
RIG_SCORE:
0.7347
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R2352C
DO8898
COAD
ICGC
ASTTT
DEG_SPOP_SBC_1
0.3056
p.P2346L
Sarc9371
bone
COSMIC
ASTTT
DEG_SPOP_SBC_1
0.75
Drug responses associated with BPTF mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ASTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60641
Clathrin coat assembly protein AP180
DEG_SPOP_SBC_1
424:428
ASTTT
SPOP
0.9865
More...
P81274
G-protein-signaling modulator 2
DEG_SPOP_SBC_1
519:523
ASTTT
SPOP
0.9496
More...
Q12830
Nucleosome-remodeling factor subunit BPTF
DEG_SPOP_SBC_1
2347:2351
ASTTT
SPOP
0.9971
More...
Q6ZVD8
PH domain leucine-rich repeat-containing protein phosphatase 2
DEG_SPOP_SBC_1
1056:1060
ASTTT
SPOP
0.9961
More...
Q96H15
T-cell immunoglobulin and mucin domain-containing protein 4
DEG_SPOP_SBC_1
134:138
ASTTT
SPOP
0.999
More...
Q9UPN6
SR-related and CTD-associated factor 8
DEG_SPOP_SBC_1
148:152
ASTTT
SPOP
0.9821
More...