DegronMD

Uniprot ID: Q6ZVD8

Source protein: PH domain leucine-rich repeat-containing protein phosphatase 2

Source gene: PHLPP2

Class: DEG_SPOP_SBC_1

Location: 1056:1060

E3 ligase: SPOP

DEGRON score: 0.9961

ASA_SCORE: 76.46

COIL: 0.8622

CONS_SCORE: 0.3397

DSS_SCORE: 0.4635

HELIX: 0.0736

FCONS_SCORE: 0.9893

RIG_SCORE: 0.7599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1053A	TCGA-B5-A1MR	UCEC	TCGA	ASTTT	DEG_SPOP_SBC_1	0.25
p.V1053A	DO41758	UCEC	ICGC	ASTTT	DEG_SPOP_SBC_1	0.25
p.V1053A	SIDM00245	Small Cell Lung Carcinoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.25
p.V1053A	ACH-001131	Skin Cancer	CCLE	ASTTT	DEG_SPOP_SBC_1	0.25
p.V1053A	MS-1	lung	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.25
p.P1050L	TCGA-ZF-A9R7	BLCA	TCGA	ASTTT	DEG_SPOP_SBC_1	0.1667
p.P1065H	DO233612	GACA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.1944
p.A1064D	DO229045	LICA	ICGC	ASTTT	DEG_SPOP_SBC_1	0.2222
p.L1049V	SIDM00613	Glioblastoma	GDSC	ASTTT	DEG_SPOP_SBC_1	0.1389
p.L1049V	KALS-1	central_nervous_system	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.1389
p.M1064L	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ASTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	424:428	ASTTT	SPOP	0.9865	More...
P81274	G-protein-signaling modulator 2	DEG_SPOP_SBC_1	519:523	ASTTT	SPOP	0.9496	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	2347:2351	ASTTT	SPOP	0.9971	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	1056:1060	ASTTT	SPOP	0.9961	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	134:138	ASTTT	SPOP	0.999	More...
Q9UPN6	SR-related and CTD-associated factor 8	DEG_SPOP_SBC_1	148:152	ASTTT	SPOP	0.9821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons