DegronMD

Uniprot ID: O60641

Source protein: Clathrin coat assembly protein AP180

Source gene: SNAP91

Class: DEG_SCF_FBW7_1

Location: 314:321

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 99.35

COIL: 0.9556

CONS_SCORE: 0.2663

DSS_SCORE: 0.6323

HELIX: 0.019

FCONS_SCORE: 0.9929

RIG_SCORE: 0.6276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D323G	TCGA-B5-A1MR	UCEC	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	0.2778
p.P327L	TCGA-C5-A2LX	CESC	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	0.1667
p.T321N	TCGA-CA-6717	COAD	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	0.8166
p.D323N	TCGA-ER-A193	SKCM	TCGA	PNSTPAKT	DEG_SCF_FBW7_1	0.2778
p.P325L	DO49004	CESC	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	0.6667
p.T319N	DO8264	COAD	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	0.7055
p.T331N	DO229038	LICA	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	0.0556
p.P324S	DO220903	MELA	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	0.6944
p.T331A	DO222908	MELA	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	0.0556
p.D321N	DO47368	SKCM	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	0.6932
p.D321G	DO41758	UCEC	ICGC	PNSTPAKT	DEG_SCF_FBW7_1	0.7198
p.A308T	SIDM02021	Esophageal Carcinoma	GDSC	PNSTPAKT	DEG_SCF_FBW7_1	0.1667
p.A319T	SIDM00333	Endometrial Carcinoma	GDSC	PNSTPAKT	DEG_SCF_FBW7_1	0.6028
p.A319T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PNSTPAKT	DEG_SCF_FBW7_1	0.6028
p.A319T	MFE-319	endometrium	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	0.6028
p.P307S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PNSTPAKT	DEG_SCF_FBW7_1	0.1389
p.P307S	H513	pleura	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	0.1389
p.A317T	MFE-319	endometrium	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	0.7139
p.A318S	MDA-MB-468	breast	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	0.7588
p.P305S	H513	pleura	COSMIC	PNSTPAKT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SCF_FBW7_1	314:321	PNSTPAKT	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons